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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes (iGDM)

C
Christina M. Scifres, MD
18 years - 45 years
Female
Interventional
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
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Investigating Pacing Methods for Heart Failure Treatment

T
Tony Navarrete
18 years - 100 years
All genders
Interventional
This study investigates two pacing methods for treating heart failure in patients with a specific heart condition. Heart failure is when the heart can't pump blood as well as it should. The study is comparing two types of cardiac-resynchronization therapy (CRT): biventricular pacing and pacing at the His or left …
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Cardiovascular Health Study in Testicular Cancer Survivors

N
Nabil Adra, MD
18 years - 100 years
Male
The purpose of this study is to investigate the long-term effects of chemotherapy and bone marrow transplant on the heart health of testicular cancer survivors. Testicular cancer often affects young adult males, and the treatment can include chemotherapy with platinum-based drugs. This study looks at changes in cholesterol, hormones, and …
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Investigation of Treatment Combinations for Advanced Non-Small Cell Lung Cancer

R
Rohan Maniar
18 years - 100 years
All genders
Phase 2/3
This study investigates the effects of adding an investigational medication, cemiplimab, to the usual treatment of docetaxel and ramucirumab for patients with stage IV or recurrent non-small cell lung cancer. This type of lung cancer is advanced and may have returned after previous treatment. Cemiplimab is a monoclonal antibody that …
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STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis (STTEPP)

E
Evan Fogel, MD
18 years or above
All genders
Phase 1
Interventional
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain fromhronic pancreatitis (CP). This pilot trial will test the feasibility of the study design andvide reassurance regarding the tolerability and safety of lacosamide used concomitantly with …
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A Randomized Phase II Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas

S
Samantha Armstrong
18 years - 100 years
All genders
Phase 2
What is the purpose of this study?This phase II trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started to other places in the …
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A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor.

S
Sandeep Batra, MD
3 years - 30 years
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients withgerminomatous germ cell tumors (NGGCT) that have not spread to other parts of the brainbody (localized). This study has …
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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

D
David Clark
18 years or above
Accepts healthy volunteer
All genders
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents thezed integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD2019 and beyond.
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Pregnancy Data Repository to Assess Management of Type 1 Diabetes with Diabetes Technology (PRAM-T1D)

C
Christina M. Scifres, MD
18 years - 100 years
All genders
Observational
What is the purpose of this study?The study is being done because we want to learn more about how people with type 1 diabetes in the United States manage their diabetes during pregnancy. We will enroll pregnant individuals with type 1 diabetes to participate in the PRAM-T1D registry, which will …
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Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Brain Metastases from Small Cell Lung Cancer.

K
Kevin Shiue
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. …
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