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Found 645 iu-health-enterprise-system trials

A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Stigma in Lung Cancer and Tobacco-Related Cancers

B
Bharathi Muthusamy
18 years - 100 years
All genders
This study investigates the stigma experienced by patients with lung cancer and other tobacco-related cancers, such as pancreatic adenocarcinoma, renal cell carcinoma, and urothelial carcinoma. A stigma is a mark of disgrace associated with a particular condition. The purpose of this study is to understand how stigma affects patients with …
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Investigating the Effectiveness of Investigational Medicine in Metastatic or Recurrent Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 3
This study investigates the effectiveness and safety of an investigational medication compared to the investigator's choice of monotherapy treatment in patients with head and neck squamous cell carcinoma (HNSCC) that is incurable, metastatic, or recurrent. HNSCC is a type of cancer that occurs in the squamous cells lining the head …
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A Phase II Trial Evaluating Chemotherapy Followed by Response-Based Reduced Radiation Therapy for Patients With Central Nervous System Germinomas

S
Sandeep Batra, MD
3 years - 30 years
All genders
Phase 2
What is the purpose of this study?This phase II trial studies how well lower dose radiotherapy after chemotherapy works in treating children with central nervous system (CNS) germinomas. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Carboplatin is in a class …
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A Randomized Phase II Study Comparing Cytarabine + Daunorubicin(7+3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin +Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome+ Venetoclax in Patients Aged 59 or Younger Who are Considered High-Risk(Adverse) Acute Myeloid Leukemia as Determined by MYELOMATCH; AMyeloMATCH Clinical Trial

R
Rita Assi
18 years - 59 years
All genders
Phase 2
What is the purpose of this study?This phase II MyeloMATCH treatment trial tests whether the standard approach of cytarabine and daunorubicin in comparison to the following experimental regimens works to shrink cancer in patients with high risk acute myeloid leukemia (AML): 1) daunorubicin and cytarabine liposome alone; 2) cytarabine and …
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Identification of Gut Microbiome and Metabolome Biomarkers in Diabetes

H
Heba Ismail
1 years - 75 years
All genders
Observational
What is the purpose of this study?The purpose of this study is to evaluate the gut microbiome and circulating microbial metabolites of children and adults with prediabetes and diabetes so we can compare the differences across different stages of diabetes but also across different forms of diabetes and different age …
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A Phase III Trial of One vs. Two Years of Maintenance Olaparib, with or without Bevacizumab, in Patients with BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy

J
Jessica Parker Metter
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme …
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Study on Cognitive Effects of Childhood-Onset Systemic Lupus Erythematosus

S
Stacey Tarvin, MD
21 years or below
All genders
Observational
This study investigates how childhood-onset neuropsychiatric systemic lupus erythematosus (NPSLE) affects cognitive functions over time. Systemic lupus erythematosus (SLE) is a disease where the immune system attacks the body, causing inflammation and damage. The study uses a tool called pedANAM to assess cognitive and behavioral functions in children with this …
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Study of Investigational Medication for Teens with Belly Pain and Bathroom Trouble

E
Erik David Andrewski
12 years - 17 years
All genders
Interventional
This study investigates the effects of an investigational medication for treating Irritable Bowel Syndrome with Constipation (IBS-C) in teenagers. IBS-C is a condition where the belly hurts and there is trouble going to the bathroom. This study is for children aged 12 to less than 18 years old.During the study, …
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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

S
Sandeep Batra, MD
1 month - 21 years
All genders
Phase 3
Interventional
What is the purpose of this study?Rhabdomyosarcoma is a type of cancer that occurs in the soft tissues in the body. This phaseutcomes in patients with very low risk rhabdomyosarcoma (VLR-RMS) while decreasing the burden of therapy using treatment with 24 weeks of vincristined dactinomycin (VA) and examines the use …
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Investigating Levocarnitine for Reducing Liver Issues in Leukemia Treatment

R
Rachael Schulte
15 years - 40 years
All genders
This study investigates whether adding levocarnitine to chemotherapy regimens can reduce liver problems, specifically conjugated hyperbilirubinemia, in adolescents and young adults with Acute Lymphoblastic Leukemia (ALL). Conjugated hyperbilirubinemia is a condition where there is too much bilirubin, a substance made during the breakdown of red blood cells, in the blood. …
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