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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Fazirsiran in the Treatment of Alpha-1 Antitrypsin Deficiency-Associated Liver Disease With METAVIR Stage F1 Fibrosis

R
Raj Vuppalanchi, MD
18 years - 75 years
All genders
Phase 3
Interventional
Why is this study being done?In some people, the liver makes an abnormal version of the alpha-1 antitrypsin (AAT) protein, called Z-AAT. Making an abnormal version of the AAT protein can result in liver disease as Z-AAT builds up in liver cells, which leads to liver problems such as liver …
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A Phase 3, Open-label, Multicenter, Randomized Study to Evaluate the Efficacy and Safety of Romosozumab Compared with Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

E
Erik Imel, MD
5 years - 17 years
All genders
Phase 3
Interventional
What is the purpose of this study?The primary objective of this study is to evaluate the effect of romosozumab treatment for 12-months compared with bisphosphonate(s) on the number of clinical fractures at 12-months; the number of any fractures at 12-months and change in lumbar spine bone mineral density (BMD) Z-score …
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Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer (DeLLphi-304)

G
Greg Durm, MD
18 years or above
All genders
Phase 3
Interventional
What is the purpose of this study?The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for …
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A Study of DSP107 Alone and in Combination With Atezolizumab for Patients With Advanced Solid Tumors

R
Rohan Maniar
18 years or above
All genders
Phase 1/2
Interventional
What is the purpose of this study?Part 1: A first-in-human, open-label, Phase I dose escalation study of DSP107 monotherapy and combination therapy with atezolizumab in patients with advanced solid tumors. Part 2: Preliminary efficacy assessment of DSP107 in combination with atezolizumab in second or third line treatment of non small …
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Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

V
Varun Mittal
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?This is a research study being done to see if adding a drug called epcoritamab to “salvage chemotherapy” GDP (gemcitabine + cisplatin, with dexamethasone) will better treat cancer than using chemotherapy alone.  THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology …
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A Multicenter Randomized Controlled Trial of Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia (The SURVENT Trial)

M
Mohammad Al-Haddad, MD
18 years or above
All genders
Interventional
What is the purpose of this study?The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. This is a multicenter study involving several academic, community and private hospitals around the United States. …
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Investigating the Effects of an Investigational Medication on Stress Responses After Motor Vehicle Collisions

P
Paul Musey, MD
18 years - 55 years
All genders
Interventional
This study investigates the effects of an investigational medication on reducing acute stress reactions and acute stress disorder following a motor vehicle collision. Acute stress reactions are immediate psychological responses to a traumatic event, which can develop into acute stress disorder if symptoms persist. The purpose of this study is …
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Research Study on Heart Failure and Kidney Function

W
Wayne Gray
18 years - 100 years
All genders
Phase 3
Interventional
This study investigates the effects of an investigational medication on heart failure and kidney function. Heart failure is a condition where the heart cannot pump blood as well as it should. This study compares the investigational medication to another treatment to see how they affect heart failure events and cardiovascular …
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Investigating the Safety and Effects of an Investigational Medication in Children with ANCA-associated Vasculitis

S
Stacey Tarvin, MD
6 years - 17 years
All genders
Phase 3
Interventional
This study investigates the safety and effects of an investigational medication combined with a regimen containing either rituximab or cyclophosphamide in children with ANCA-associated vasculitis (AAV). ANCA-associated vasculitis is a condition where the body's immune system mistakenly attacks blood vessels, causing inflammation. The study focuses on children aged 6 to …
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Study on Investigational Medication for X-linked Hypophosphatemia (XLH)

E
Erik Imel, MD
18 years - 65 years
All genders
Phase 1/2
Interventional
This study investigates the safety and effectiveness of an investigational medication for adults with X-linked hypophosphatemia (XLH). XLH is a rare genetic disorder that affects the bones and teeth, leading to low levels of phosphate in the blood, which can cause bone pain and deformities. The study is open-label, meaning …
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