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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study on Preparation Therapy for Women Undergoing Pelvic Radiotherapy

N
Namita Agrawal
18 years or above
Female
Interventional
This study investigates the feasibility of adding pre-rehabilitation pelvic health physical therapy to the standard radiation treatment plan for women with certain types of cancer. These include cervical, vaginal, vulvar, uterine, or anal cancer. Participants will receive education on using a vaginal dilator during their treatment. The study will also …
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DAY101 vs. Standard of Care Chemotherapy in Pediatric Patients With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

M
Michael Ferguson, MD
25 years or below
All genders
Phase 3
Interventional
What is the purpose of this study?This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in patients with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring front-line …
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Study on Safety and Effects of Investigational Antibiotic in Infants

A
Anna Elizabeth Thomas
9 months or below
All genders
Phase 1/2
Interventional
This study investigates the safety and effects of an investigational medication for treating infections caused by gram-negative bacteria in newborns and infants. Gram-negative bacteria are a type of bacteria that can cause various infections and are known for their resistance to antibiotics. The investigational medication is a combination of two …
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A Phase 1/2 Trial of CBL0137 in Patients with Relapsed or Refractory Solid Tumors including CNS Tumors and Lymphoma

B
Brian Weiss
1 years - 21 years
All genders
Interventional
What is the purpose of this study?This phase I/II trial evaluates the best dose, side effects and possible benefit of CBL0137 in treating patients with solid tumors, including central nervous system (CNS) tumors or lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Drugs, such as …
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Study on the Use of Investigational Medication with Targeted Therapy for Cancer that has Spread from the Pancreas

A
Anita Turk, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates the use of an investigational medication along with a targeted therapy called olaparib for patients with metastatic pancreatic cancer. Metastatic pancreatic cancer is when the cancer has spread from the pancreas to other parts of the body. The study focuses on patients with specific genetic mutations called …
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A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With The Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

B
Bryan Schneider, MD
18 years - 100 years
All genders
Phase 3
Interventional
What is the purpose of this study?This Phase III, randomized, open-label, multicenter study will evaluate the efficacy andy of giredestrant plus everolimus compared with the physician's choice of endocrineherapy plus everolimus in participants with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer …
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Study on Treatment After Initial Therapy for Residual Triple Negative Breast Cancer

B
Bryan Schneider, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates treatments for patients with residual triple negative breast cancer, a type of breast cancer that does not have estrogen, progesterone, or HER2 receptors. The study uses circulating tumor DNA (ctDNA) to assign participants to different treatment arms based on their genomic markers. Participants with ctDNA positivity and …
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A Pilot Study in the Treatment of Refractory Epstein-Barr Virus (EBV) Infection with Related Donor EBV Cytotoxic T-Lymphocytes in Children, Adolescents and Young Adult Recipients - NYMC 581

S
Scott Goebel, MD
1 month - 79 years
All genders
Phase 2
Interventional
What is the purpose of this study?Related donor Epstein-Barr Virus (EBV) specific cytotoxic T cells (CTLs) manufactured withhe Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children,dolescents and young adults with refractory EBV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid …
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Investigating Maintenance Treatment or Observation for Germ Cell Tumors

N
Nabil Adra, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates maintenance treatment with oral etoposide or observation in patients with relapsed germ cell tumors (GCT) who have received high-dose chemotherapy and peripheral blood stem cell transplant. Germ cell tumors are a type of cancer that begins in the cells that give rise to sperm or eggs. This …
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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

M
Marissa Just
30 years or below
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies how well combination chemotherapy works in treating patients withwly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). Drugs used in chemotherapy regimens suchH-3 (vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, …
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