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Found 645 iu-health-enterprise-system trials

A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigating the Use of a Blood Test for Cancer Markers in Advanced Lung Cancer Treatment

N
Nasser Hanna, MD
18 years - 100 years
All genders
Phase 2
Interventional
This study investigates the use of circulating tumor DNA (ctDNA) to personalize treatment for patients with stage III non-small cell lung cancer (NSCLC). The purpose is to use ctDNA analysis to guide therapy decisions, instead of relying solely on clinical or radiographic evidence of disease. This approach aims to tailor …
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Study of Investigational Medication with or without Investigational Medication for Advanced Breast Cancer

K
Kathy Miller, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates the effects of an investigational medication alone compared to the same medication combined with tocilizumab in patients with advanced breast cancer. Advanced breast cancer includes conditions such as metastatic triple negative or ER-low breast cancer. This study involves Black and non-Black patients and aims to understand how …
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Investigational Treatment Study for Platinum-Resistant Ovarian Cancer

L
Lisa Landrum, MD, PhD, MS
18 years or above
Female
Phase 3
Interventional
This study investigates treatments for women with platinum-resistant epithelial ovarian cancer, which is a type of cancer that does not respond to platinum-based chemotherapy. The purpose is to compare the effects of different treatments, including an investigational medication called nemvaleukin, either alone or in combination with another treatment, pembrolizumab, against …
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Study of Investigational Treatment for HER2-positive Breast Cancer

T
Tarah Ballinger, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates treatments for people with HER2-positive breast cancer. HER2-positive means that the cancer cells have more HER2 protein than normal, which can cause cancer cells to grow. The study looks at using a combination of investigational medication injections and hormone therapy after surgery. The investigational medications are trastuzumab …
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Study on Breast Cancer Treatment with Hormone and Radiation Therapy

N
Naoyuki Saito, MD
50 years - 70 years
All genders
Phase 3
Interventional
This study investigates the treatment of breast cancer in patients who have hormone-sensitive, HER-2 negative tumors with a low recurrence score. The purpose is to understand if breast conservation surgery with only endocrine therapy is as effective as combining it with radiation therapy in preventing the return of cancer in …
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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

B
Brian Weiss
12 months - 30 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits ofgavivint in treating patients with solid tumors that has come back (recurrent) or does notd to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help …
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Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

J
Jessica Parker Metter
18 years - 100 years
Female
Phase 3
Interventional
What is the purpose of this study?The OnPrime study is a multi-center, randomized open-label phase 3 study evaluating the safety and efficacy of Olvi-Vec followed by platinum-doublet chemotherapy and bevacizumab compared to the Active Comparator Arm with Physician's Choice of chemotherapy and bevacizumab in women diagnosed with platinum-resistant/refractory ovarian cancer …
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Study on the Body's Defense System Against Infections and Diseases

M
Mark Kaplan
3 years - 100 years
Accepts healthy volunteer
All genders
This study investigates how the immune system works to prevent infections and diseases. The immune system is important for stopping infections and tumors, but problems with it can cause diseases like asthma, autoimmune diseases, and infections. The study aims to understand these inflammatory diseases better.In this study, researchers will collect …
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Imaging Morphology of Pancreas in Diabetic Patients Following Acute Pancreatitis

T
Temel Tirkes, MD
18 years - 75 years
All genders
What is this study about?This study aims to understand how often patients develop diabetes mellitus after acute pancreatitis and understand its clinical characteristics. It also aims to identify risk factors that predict the development of diabetes mellitus.
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TROPICS

D
Daniel Cater
1 years - 17 years
All genders
Build decision support tools that can be used in future clinical trials to identify when children with septic shock should or should not be transfused with red blood cells. 
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