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Found 149 Neoplasms trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

GRONINGEN INTERNATIONAL STUDY ON SENTINEL NODES IN VULVAR CANCER III, A PROSPECTIVE PHASE II TREATMENT TRIAL

S
Sharon E. Robertson
18 years - 100 years
Female
Phase 2
What is the purpose of this study?The primary objective of this study is to investigate the safety of replacing inguinofemoral lymphadenectomy by chemoradiation in early stage vulvar cancer patients with a macrometastasis (>2mm) and/or extracapsular extension in the SN. The secondary objective is to evaluate the short and long-term morbidity …
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Study of Investigational Medication with Chemotherapy for Certain Blood Cancers

B
Brian Weiss
1 year - 18 years
All genders
Phase 1
This study investigates the safety and best dose of an investigational medication combined with chemotherapy drugs, fludarabine and cytarabine, for treating certain blood cancers. The cancers include acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) that have not responded to previous treatment or have returned after …
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ARE YOU A BREAST CANCER SURVIVOR? Join Our Study and Help Researchers Learn More About Treating Cognitive Problems Attributed to Chemotherapy

ARE YOU A BREAST CANCER SURVIVOR? Join Our Study and Help Researchers Learn More About Treating Cognitive Problems Attributed to Chemotherapy

B
Brenna McDonald
18 years - 100 years
Female
ARE YOU A BREAST CANCER SURVIVOR?  HAVE YOU NOTICED ANY PROBLEMS WITH YOUR COGNITIVE FUNCTION - MEMORY, ATTENTION, ABILITY TO MULTI-TASK - AFTER COMPLETING CHEMOTHERAPY? Researchers at Indiana University School of Medicine and the University of Pittsburgh are seeking volunteers to take part in a study looking at two telehealth-delivered therapies …
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The Indiana Myeloma Registry

The Indiana Myeloma Registry

R
Rafat Abonour, MD
18 years - 100 years
All genders
Observational
WHAT IS CANCER?WHAT IS MULTIPLE MYELOMA?WHAT IS THE STUDY ABOUT?What is cancer?Each cell in your body holds a copy of your DNA. This DNA tells your cells how to do their jobs, like when to copy themselves and when to delete. Your cells copy and delete all the time. This …
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Investigational Medication for Protecting Egg-Producing Organs in Young Cancer Patients

A
Amanda J. Saraf, DO
40 years or below
Female
Phase 3
This study investigates the effects of an investigational medication on protecting the ovaries in young females with cancer who are receiving chemotherapy. Chemotherapy, particularly with alkylating agents, can harm the ovaries, making it hard to get pregnant later. The investigational medication may help by slowing down the ovaries during chemotherapy, …
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Sample Collection to Assess Physioxia in Brain Tumors

A
Angela M. Richardson, MD, PhD
18 years or above
All genders
What is the purpose of this study?The purpose of this study is to look at the effect of oxygen on tumor tissue and cerebrospinal fluid(CSF). Tissue in your body is exposed to less oxygen than is in the air around you. Traditional studies use cells and tissue kept in room …
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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

S
Sandeep Batra, MD
1 year - 50 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effect of open thoracic surgery (thoracotomy) tohoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgeryype of surgery done through a single larger incision (like …
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A Phase I/II, Open-Label Study to Investigate the Safety, Clinical Activity, Pharmacokinetics, and Pharmacodynamics of GSK3145095 Administered Alone and in Combination With Anticancer Agents Including Pembrolizumab in Adult Participants With Selected Advanced Solid Tumors

P
Patrick Loehrer, MD
18 years - 100 years
All genders
In an unbiased CRISPR screen, RIPK1 was identified as a top gene contributing to immunotherapy resistance. In addition, RIPK1 has been reported to drive pancreatic oncogenesis. In murine models, inhibition of RIPK1 kinase activity in the pancreatic tumor microenvironment leads to the replacement of tumor-permissive myeloid infiltrates with innate cells …
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Comparative Effectiveness of Interventions to Improve Screening Among Rural Women

V
Victoria Champion
50 years - 74 years
Female
The purpose of this study is to compare the effectiveness of a tailored interactive DVD (TIDVD) vs telephone patient navigation (PN) + tailored interactive DVD (TIDVD) vs Usual Care in increasing screening rates for Breast Cancer (BC), Cervical Cancer (CC), and colorectal cancer (CRC) among women 50 -74 years living …
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PHO-COG-CROOP-ADVL1312; A Phase 1/2 Study of AZD1775 (MK-1775) in Combination With Oral Irinotecan in Children Adolescents and Young Adults With Relapsed or Refractory Solid Tumors

J
James Croop, MD, PhD
1 years - 21 years
All genders
This phase I/II trial studies the side effects and best dose of WEE1 inhibitor MK-1775 and irinotecan hydrochloride in treating younger patients with solid tumors that have come back or that have not responded to standard therapy. WEE1 inhibitor MK-1775 and irinotecan hydrochloride may stop the growth of tumor cells …
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