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Found 163 Neoplasm trials

A listing of Neoplasm medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study on the Effectiveness of Investigational Medication Versus Standard Treatment for Glioblastoma, a Type of Brain Cancer

K
Kathryn Nevel
18 years - 100 years
All genders
Phase 3
This study investigates the effectiveness and safety of an investigational medication compared to a standard treatment in adults with newly-diagnosed glioblastoma. Glioblastoma is a type of brain cancer. The study aims to see if the investigational medication can improve the time patients live without the cancer getting worse and overall …
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Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Brain Metastases from Small Cell Lung Cancer.

K
Kevin Shiue
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. …
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Investigating the Safety and Effects of an Investigational Antibody-Drug Conjugate in Solid Tumors

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 1
This study investigates the safety and effects of an investigational antibody-drug conjugate in patients with advanced or metastatic solid tumors. The purpose is to understand how the investigational medication works in the body and its impact on tumors. Advanced or metastatic solid tumors are cancers that have spread beyond their …
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Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin

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Greg Durm, MD
18 years - 100 years
All genders
The purpose of this study is to compare any good and bad effects of usual radiation plus the study treatment, MEDI4736 (durvalumab), to the usual therapy of radiation plus cetuximab in patients with head and neck cancer who cannot take the drug cisplatin.
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A Phase I Study of Intra-Tumoral Injections of Ex Vivo Expanded Natural Killer Cells in Children and Young Adults With Recurrent or Progressive Supratentorial Malignant Brain Tumors

S
Scott Coven
1 years - 38 years
All genders
Phase 1
What is this study about?This phase I trial tests the safety, side effects, and best dose of ex vivo expanded natural killer cells in treating patients with cancerous (malignant) tumors affecting the upper part of the brain (supratentorial) that have come back (recurrent) or that are growing, spreading, or getting …
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Investigating Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult (AYA) Childhood Cancer Survivors

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Sandeep Batra, MD
15 years - 20 years
All genders
This study investigates a home-based physical activity program designed for Hispanic or Latino/Latina adolescent and young adult (AYA) childhood cancer survivors. After cancer treatment, some AYA survivors may experience long-term effects like weight gain, tiredness, and reduced fitness. Hispanic or Latino/Latina survivors might face a higher risk of these effects. …
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Study on Medication for Appetite Loss in Cancer

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Susan Ballinger
18 years - 100 years
All genders
Phase 3
This study investigates the effects of an investigational medication on appetite loss in patients with advanced cancer. Advanced cancer means the cancer has spread to other parts of the body. The purpose of this study is to compare the investigational medication with another usual medication to see which one is …
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A Protocol for Children and Young Adults Diagnosed with a Central Nervous System (CNS) Tumor to Assess Cognitive, Quality of Life (QOL), and Comprehensive Effects of Therapies

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Scott Coven
39 years or below
All genders
What is the purpose of this study?To longitudinally assess cognitive outcomes using an a neurocognitive screening battery in children and young adults diagnosed with a CNS tumor. To longitudinally assess the impact of specific therapies on the QOL in children and young adults diagnosed with a CNS tumor.To longitudinally assess …
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A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1/2
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
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Research Study on Investigational Medication for HER2 Expressing Tumors

J
Jonathan L. Berkowitz, MD, PhD
18 years - 120 years
All genders
Phase 2
Interventional
This study investigates an investigational medication for treating certain tumors that express a protein called HER2. HER2 is a protein that can affect the growth of some cancer cells. The study includes different types of cancers such as bladder, biliary tract, cervical, endometrial, ovarian, pancreatic, and some rare tumors.Participants will …
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