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Found 29 results for Liver Disease/Disorder
A listing of Liver Disease/Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Geometric Engineering of Liver Organoid Culture in Pediatric Liver Diseases
C
Chao Jarasvaraparn
What is the purpose of this study?Chronic liver disease (CLD) in children can be caused by a variety of conditions and have serious consequences if left untreated. Liver organoids are defined as 3D structure derived from human liver tissue and is a promising new approach to treating liver disease in …
Role of neutrophil-specific NOX2 in alcohol-induced liver injury
S
Suthat Liangpunsakul, MD
What is the purpose of this study?NADPH oxidase 2 (NOX2) is the isoform of NOX found in phagocytes including neutrophils, NOX2 activation generates reactive oxygen species (ROS) with antimicrobial activities. Patients with advanced alcoholic cirrhosis or alcoholic hepatitis are more susceptible to infections due to deficient ROS production by neutrophils. …
A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants with Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes (Synergy-Outcomes)
R
Raj Vuppalanchi, MD
This multicenter, randomized, parallel-arm, double-blind, placebo-controlled Phase 3 umbrella- type master protocol aims to create a framework for simultaneously evaluating the safety and efficacy of multiple pharmacologic agents (interventions) for the treatment of high-risk metabolic dysfunction-associated steatotic liver disease.THIS STUDY IS ENROLLING BY INVITATION ONLY - The study team will …
Microbiome alterations in the setting of intestinal failure associated liver disease
K
Katie Huff
What is the purpose of this study?Neonates who require prolonged IV nutrition (TPN) are at risk for such complications as intestinal failure associated liver disease (IFALD). In addition, it is also known that TPN and lack of nutrition through the GI tract influences the intestinal microbiome or bacteria present in …
Understanding Barriers to Alcohol Use Disorder Treatment and Digital Health Engagement Among Patients with Alcohol-Associated Liver Disease: A Mixed-Methods Formative Study
L
Lauren Nephew
From the patient perspective, stigma and fear of judgment, especially in transplant-adjacent contexts, discourage disclosure of alcohol use and engagement in treatment. Structural challenges, including transportation barriers, unstable housing, caregiving responsibilities, and financial toxicity, further limit participation in treatment. Treatment readiness may also fluctuate with stress, episodes of hepatic decompensation, …
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of Resmetirom for the Treatment of Metabolic Dysfunction- Associated Steatotic Liver Disease (Masld) in People Living With Human Immunodeficiency Virus (Hiv)
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Samer Gawrieh, MD
The purpose of this research study is to test the safety and effectiveness of the study drug, resmetirom, in participants with MASLD and HIV. This is a research study to test a drug that is already on the market with a population that was not included in the original clinical …
Collection of Liver Tissue and a Blood Sample for Future Research
N
Naga Chalasani, MD
What is the purpose of this study?The aim of this study is to collect a small sample of liver tissue and approximately 15mL of blood from patients who are undergoing elective liver biopsies for clinical purposes to establish and grow a liver tissue bank. The samples will be used for …
Unraveling the Immunological Triggers of Acute Cellular Rejection in Pediatric Liver Transplantation.
A
Abby Russi
The proposed project is designed to prospectively collect blood and tissue from patients who have received a liver transplant (for any reason) to capture the immunoceullar landscape in the periphery preceding and target tissue during acute cellular rejection. It is a longitudinal collection of clinical data without study interventions.THIS STUDY …
National Liver Cancer Screening Trial (TRACER)
N
Naga Chalasani, MD
What is this study about?The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using …
Lt-Care (Liver Transplant-Community Access for Referral Equity) Applied
L
Lauren Nephew
A previous study (25857) focused on developing a multilevel intervention addressing health related variables and other social/structural barriers faced by patients as the most prominent way to acknowledge and improve LT referral equity. The LT-CARE intervention has been designed and as a part of this protocol, will be delivered to …
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