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Found 29 Liver Disease/Disorder trials

A listing of Liver Disease/Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Geometric Engineering of Liver Organoid Culture in Pediatric Liver Diseases

C
Chao Jarasvaraparn
17 years or below
All genders
Observational
What is the purpose of this study?Chronic liver disease (CLD) in children can be caused by a variety of conditions and have serious consequences if left untreated. Liver organoids are defined as 3D structure derived from human liver tissue and is a promising new approach to treating liver disease in …
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Investigating Kidney Function Recovery in Patients Undergoing Both Liver and Kidney Transplants

M
Muhammad Jan
18 years - 100 years
All genders
This study investigates how kidney function recovers after a person receives both a liver and a kidney transplant. The purpose of this study is to see if having a liver transplant alone can improve kidney function enough that a kidney transplant might not be needed. This study is for people …
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Role of neutrophil-specific NOX2 in alcohol-induced liver injury

S
Suthat Liangpunsakul, MD
18 years - 70 years
Accepts healthy volunteer
All genders
What is the purpose of this study?NADPH oxidase 2 (NOX2) is the isoform of NOX found in phagocytes including neutrophils, NOX2 activation generates reactive oxygen species (ROS) with antimicrobial activities. Patients with advanced alcoholic cirrhosis or alcoholic hepatitis are more susceptible to infections due to deficient ROS production by neutrophils. …
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Investigating Treatments for Fatty Liver Disease Related to Metabolic Issues

R
Raj Vuppalanchi, MD
18 years - 100 years
All genders
Interventional
This study investigates metabolic dysfunction-associated steatotic liver disease (MASLD), a condition where fat builds up in the liver due to metabolic issues. The purpose of this study is to assess the safety and effectiveness of different investigational medications for adults with MASLD who are at high risk of serious liver …
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Microbiome alterations in the setting of intestinal failure associated liver disease

K
Katie Huff
18 months or below
All genders
What is the purpose of this study?Neonates who require prolonged IV nutrition (TPN) are at risk for such complications as intestinal failure associated liver disease (IFALD). In addition, it is also known that TPN and lack of nutrition through the GI tract influences the intestinal microbiome or bacteria present in …
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OnX Liver Assessment Solution Clinical Study

R
Raj Vuppalanchi, MD
22 years - 80 years
All genders
Interventional
What is the purpose of this study?This protocol’s primary aim is to assess the performance of the OnX exam on patients with suspected or confirmed liver disease with the goal of comparing the OnX output stiffness estimates to FibroScan® liver stiffness measurements. Our primary objectives are to assess whether the …
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Collection of Liver Tissue and a Blood Sample for Future Research

N
Naga Chalasani, MD
18 years or above
All genders
What is the purpose of this study?The aim of this study is to collect a small sample of liver tissue and approximately 15mL of blood from patients who are undergoing elective liver biopsies for clinical purposes to establish and grow a liver tissue bank.  The samples will be used for …
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Investigating Immune Responses in Children After Liver Transplant

A
Abby Russi
19 years or below
All genders
Observational
This study investigates the immune responses in children who have had a liver transplant. The purpose is to understand how the body's immune system acts before and during a problem called acute cellular rejection, which can happen after a transplant. Acute cellular rejection is when the body's immune system attacks …
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National Liver Cancer Screening Trial (TRACER)

N
Naga Chalasani, MD
18 years - 85 years
All genders
What is this study about?The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using …
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Effect of the HCC-EduLink Intervention

L
Lauren Nephew
18 years - 100 years
All genders
The objective of this study is to pilot test a multi-level intervention designed to address patient- and system-level social and structural determinants of health (SSDOH) variables and facilitate access to curative hepatocellular carcinoma (HCC) therapies, including liver transplantation and resection, in a cohort of Black patients with Barcelona Clinic Liver …
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