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Found 594 results for IU Health Enterprise System
A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
A
Anna Elizabeth Thomas
The purpose of this study is to determine if an investigational drug can prevent Bronchopulmonary Dysplasia, reducing the burden of chronic lung disease in extremely premature infants, as compared to extremely premature infants receiving standard neonatal care alone.THIS STUDY IS ENROLLING BY INVITATION ONLY
A Randomised, Double-Blind, Placebo-Controlled Trial with an Open-Label Extension to Assess the Pharmacokinetics, Safety, and Efficacy of Empagliflozin Tablets in Paediatric Patients with Chronic Kidney Disease (Empa-Kidney Kids)
M
Myda Khalid
This study is open to children aged 2 to 17 with chronic kidney disease (CKD). The purpose of this study is to find out if a medicine called empagliflozin helps children and adolescents with CKD. Other goals of the study are to find out how empagliflozin is tolerated and handled …
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
S
Sandeep Batra, MD
This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein …
A Phase 3, Multicenter, Prospective Open-Label Study to Evaluate the Diagnostic Performance of [18F]Fapi-74 Pet/Ct for the Detection of Metastatic Disease in Adults with Pancreatic Ductal Adenocarcinoma
C
Cindy Yuan
This is a multi-site, open-label, non-randomized, single dose study to assess the clinical utility of [¹⁸F]FAPI-74 PET/CT in the detection of metastatic disease in individuals with pathologically confirmed pancreatic ductal adenocarcinoma. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are …
A Phase 2A Multicenter, Randomized, Platform Study of Targeted Therapies for the Treatment of Adult Subjects with Moderate to Severe Crohn's Disease
M
Monika Fischer, MD
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may …
A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Nucresiran in Patients with Transthyretin-Mediated Amyloidosis with Cardiomyopathy
N
Noel Dasgupta
This is a Phase 3, global, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy, safety, PK, and PD of nucresiran in adult patients with ATTR amyloidosis (hereditary or wt) with cardiomyopathy. The purpose of this study is to:Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and …
A Phase 2B/3 Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Protocol to Evaluate the Efficacy and Safety of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
M
Monika Fischer, MD
The purpose of this study is to evaluate how-well icotrokinra works (clinical efficacy) and how safe it is (safety) in participants with moderately to severely active Crohn's disease (CD; a long-term condition causing severe inflammation of the intestinal tract).THIS STUDY IS ENROLLING BY INVITATION ONLY
A Phase 3B/4, Multicenter, Parallel-Group, Double-Blind, Placebo Controlled, Two-Arm, Long-Term Study to Evaluate the Safety and Efficacy of Saroglitazar Magnesium on Clinical Outcomes in Participants With Primary Biliary Cholangitis (Pbc)
R
Raj Vuppalanchi, MD
The purpose of this study is to evaluate the effect of saroglitazar magnesium compared to placebo, based on time to the first occurrence of the defined clinical outcome events in participants with PBC.THIS STUDY IS ENROLLING BY INVITATION ONLY
Early Detection of Neonatal Opioid Withdrawal Syndrome Using a Novel Cerebral Monitor
A
Anna Elizabeth Thomas
This study is being conducted to investigate whether blood flow and/or oxygenation in the brain of babies exposed to opioids during pregnancy can predict the severity of neonatal opioid withdrawal symptoms (NOWS). This study will use a novel, safe, non-invasive brain monitoring device to measure blood flow and oxygen levels …
A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Protocol in Adults With an Open Label Study in Adolescents to Evaluate the Efficacy and Safety of Induction and Maintenance Therapy With Icotrokinra in Participants With Moderately to Severely Active Ulcerative Colitis
M
Monika Fischer, MD
The purpose of this protocol is to evaluate the efficacy (how well it works), safety and tolerability of oral icotrokinra as therapy in adult and adolescent participants with moderately to severely active ulcerative colitis (UC, a chronic disease of the large intestine in which the lining of the colon becomes …
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