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Found 645 iu-health-enterprise-system trials

A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study on Treatment for JMML

S
Sandeep Batra, MD
1 month - 21 years
All genders
Phase 1/2
This study investigates treatment options for juvenile myelomonocytic leukemia (JMML), a rare type of blood cancer that affects young children. JMML is a condition where the bone marrow makes too many white blood cells, which can lead to various health problems. The purpose of this study is to test the …
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National Liver Cancer Screening Trial (TRACER)

N
Naga Chalasani, MD
18 years - 85 years
All genders
What is this study about?The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using …
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Rapid Autopsy Protocol for Patients with Small Cell Lung Cancer

S
Shadia Jalal, MD
18 years - 100 years
All genders
What is the purpose of this study?This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection. This proposal is a collaboration between scientists, lung cancer physicians, pathologists, …
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Comparing treatment, costs, and patient outcomes of close-range vs long-range GSWs to the upper extremity.

E
Erin Weber
18 years - 100 years
All genders
Observational
What is this study about?The purpose of this study is to measure outcomes related to close-range and long-range gunshot wounds to the hand, wrist, and arm.   THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients will be identified and recruited by Dr. Weber and other hand surgeons providing care for the …
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Defining the Pathobiology of Coarctation of the Aorta

B
Benjamin Landis, MD
1 year - 100 years
All genders
Observational
What is this study about?Coarctation of the aorta (CoA) tissues contain distinctive cell populations, and comprehensive analysis of these cells will provide understanding of cell abnormalities that are driving CoA. We want to define these types of cells that are abnormally located in the diseased aortic tissues of neonates with …
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Investigating the Effectiveness of Immunotherapy in Recurrent Endometrial Cancer

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
This study investigates the effectiveness of using a combination of investigational medications, nivolumab and ipilimumab, compared to nivolumab alone in treating patients with recurrent endometrial cancer. Endometrial cancer is a type of cancer that begins in the lining of the uterus. This study focuses on a specific type of endometrial …
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Phase Ib Active Immunotherapy Trial (Expansion) with a Combination of Two Chimeric (Trastuzumab-like and Pertuzumab-like) HER-2 B Cell Peptide Vaccine emulsified in ISA 720 Adjuvant in Patients with Advanced Solid Tumors

K
Kathy Miller, MD
18 years - 100 years
All genders
Phase 1/2
What is the purpose of this study?This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.THIS …
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Investigating Chemoradiation (Combination of Chemotherapy and Radiation Therapy) for Early Stage Vulvar Cancer

S
Sharon E. Robertson
18 years - 100 years
Female
Phase 2
This study investigates the safety of using chemoradiation instead of surgery for early stage vulvar cancer. Vulvar cancer is a type of cancer that affects the external female genitalia. In some cases, cancer spreads to nearby lymph nodes. This study looks at patients with a macrometastasis, which means the cancer …
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A multi-center, open-label study to determine the dose and safety of oral asciminib in pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP), previously treated with one or more tyrosine kinase inhibitors

R
Rachael Schulte
1 years - 18 years
All genders
Phase 1/2
What is the purpose of this study?The aim of this study is to support development of asciminib in the pediatric population (1 to <18 years) with Philadelphia chromosome positive chronic myeloid leukemia in chronic phase (PH+ CML-CP) previously treated with one or more Tyrosine kinase inhibitor (TKIs). THIS STUDY IS ENROLLING …
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Indiana Neuroimaging and Biomarker Study of Anti-Amyloid Treatments

D
Donna Wilcock
100 years or below
All genders
Observational
What is the purpose of this study?The goal of this research is to create a repository of brain imaging and biological samples to study individuals undergoing clinical treatment with anti-amyloid therapies and compare them with samples and images from healthy individuals and cognitively impaired individuals not receiving these treatments. We …
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