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Found 700 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study on the Long-Term Effects of an Investigational Medication in Early Alzheimer's Disease

J
James Stevens
50 years - 85 years
All genders
Phase 3
Interventional
This study investigates the long-term effects of an investigational medication in individuals with early Alzheimer's disease who have the APOE4/4 genotype. The APOE4/4 genotype is a specific genetic variation associated with an increased risk of Alzheimer's disease. The purpose of this investigation is to evaluate the safety and effectiveness of …
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A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in Patients With Postural Orthostatic Tachycardia Syndrome

A
Alex Barboi
18 years - 55 years
All genders
Phase 2
Interventional
What is the purpose of this study?This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS.The aim of the study is to see how safe, tolerable, and effective the study drug is.The study is looking at several other research questions, …
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A phase 1, open-label, single arm study to evaluate pharmacokinetics, safety, and tolerability of Saroglitazar Magnesium dosed on alternate days in subjects having moderate hepatic impairment with cirrhosis due to cholestatic liver disease

R
Raj Vuppalanchi, MD
18 years - 80 years
All genders
Phase 1
Interventional
To evaluate PK after Saroglitazar Magnesium 1 mg dose on alternate days in subjects with moderate hepatic impairment with cirrhosis due to CLD based on Child-Pugh-Turcotte (CPT) score.To assess safety and tolerability of Sa-roglitazar Magnesium 1 mg dose on alter-nate days in subjects with moderate hepatic impairment with cirrhosis due …
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Geometric Engineering of Liver Organoid Culture in Pediatric Liver Diseases

C
Chao Jarasvaraparn
17 years or below
All genders
Observational
What is the purpose of this study?Chronic liver disease (CLD) in children can be caused by a variety of conditions and have serious consequences if left untreated. Liver organoids are defined as 3D structure derived from human liver tissue and is a promising new approach to treating liver disease in …
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A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Patients With Graves' Disease

C
Cary Mariash, MD
18 years - 75 years
All genders
Phase 2/3
Interventional
This is a study to assess the efficacy, safety, and tolerability of IMVT-1402 in adult participants with Graves' disease (GD) who are hyperthyroid despite antithyroid drug (ATD) treatment.The primary objective of this study is to evaluate the efficacy of IMVT-1402 versus placebo as assessed by T3 (total triiodothyronine [T3] or …
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A Historical Cohort, Multicenter Study to Characterize the Management, Clinical Course, and Outcomes of Pregnancies in Participants Who Have Experienced a Pregnancy With Severe HDFN

H
Hiba Mustafa, MD
18 years - 100 years
All genders
Observational
What is the purpose of this study?The purpose of this study is to better understand how pregnancies affected by severe Hemolytic Disease of the Fetus and Newborn (HDFN) are managed and what outcomes result from different treatment approaches. By analyzing past pregnancies from 2006 to 2023, this study aims to …
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Investigating the Effects of an Investigational Medication on Long-term Lung Disease (COPD)

M
Marc Rovner
18 years - 100 years
All genders
Phase 3
Interventional
This study investigates the effects of an investigational medication on people with moderate to very severe Chronic Obstructive Pulmonary Disease (COPD). COPD is a long-term lung disease that makes it hard to breathe. The purpose of this study is to see how well the investigational medication works compared to a …
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Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients

L
Leslie Hulvershorn, MD, MSc
5 years - 17 years
All genders
Interventional
This is a multicenter study in pediatric patients aged 5 to 17 years with a primary diagnosis of Autism Spectrum Disorder associated with irritability to evaluate the efficacy of high and low doses of lumateperone compared to placebo for the treatment of irritability associated with Autism Spectrum Disorder and to …
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Detecting Prostate Cancer Return with Imaging

C
Clinton Bahler, MD
18 years - 100 years
Male
Phase 3
This study investigates how well a special scan can find prostate cancer that has come back after treatment. Prostate cancer is a disease where cells in the prostate grow out of control. The study uses a technique called PET/CT, which stands for Positron Emission Tomography and Computed Tomography. This scan …
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Investigating Sleep and Daily Living in Patients with Dravet Syndrome and Lennox-Gastaut Syndrome (Severe Epilepsy Disorders)

J
Jason Santiago
18 years - 100 years
All genders
Observational
This study investigates sleep disturbances, behavior, and daily activities in patients with Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) who are starting treatment with an investigational medication. Dravet Syndrome and Lennox-Gastaut Syndrome are conditions that affect the brain and can cause seizures. This study looks at how the treatment affects …
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