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Found 682 results for in-health
A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Phase 2 Study to Evaluate the Safety and Efficacy of Atacicept in Multiple Autoimmune Glomerular Diseases (PIONEER)
M
Myda Khalid
The purpose of this study is to evaluate the safety and tolerability of atacicept in adult and adolescent participants and to measure the effect in reducing proteinuria and preserving renal function.THIS STUDY IS ENROLLING BY INVITATION ONLY
A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants with Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes (Synergy-Outcomes)
R
Raj Vuppalanchi, MD
This multicenter, randomized, parallel-arm, double-blind, placebo-controlled Phase 3 umbrella- type master protocol aims to create a framework for simultaneously evaluating the safety and efficacy of multiple pharmacologic agents (interventions) for the treatment of high-risk metabolic dysfunction-associated steatotic liver disease.THIS STUDY IS ENROLLING BY INVITATION ONLY - The study team will …
A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of Vamifeport in Adult Subjects with Hfe-Related Hereditary Hemochromatosis
E
Eric Orman
This is a phase 2, multicenter, randomized, placebo-controlled, double-blind, parallel-group, proof-of-concept study to assess vamifeport in adult participants with homeostatic iron regulator gene-related hereditary hemochromatosis (HFE-HH). The primary objective of the study is to assess the effect of vamifeport treatment on magnetic resonance imaging (MRI)-based liver iron concentration (LIC) in …
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study to Investigate the Safety and Efficacy of Efimosfermin Alfa in Participants With Biopsy-Confirmed F2- or F3-Stage Metabolic Dysfunction-Associated Steatohepatitis (Mash) (Zenith-1)
R
Raj Vuppalanchi, MD
The purpose of this study is to assess the safety and efficacy of efimosfermin alfa in the resolution of steatohepatitis and improvement of liver-related clinical outcome compared to placebo in individuals with MASH and biopsy-confirmed F2- or F3-stage fibrosis.THIS STUDY IS ENROLLING BY INVITATION ONLY
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
A
Anthony Ross
This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a …
A Phase 2 Study of Mutant-Selective Pi3Kα Inhibitor, Rly-2608, in Adults and Children with Pik3Ca Related Overgrowth Spectrum and Malformations Driven by Pik3Ca Mutation
R
Rachael Schulte
This is a 3-part Phase 2 randomized study evaluating the safety and efficacy of the mutant-selective PI3Kα inhibitor, RLY-2608, in adults and children with PIK3CA Related Overgrowth Spectrum (PROS) and malformations driven by PIK3CA mutation. THIS STUDY IS ENROLLING BY INVITATION ONLY
A type I hybrid effectiveness-implementation study of a parent-centered tool to promote shared decision-making in hypospadias care
M
Martin Kaefer, MD
What is the purpose of this study?Aim 1. Compare the effect of the Hypospadias Hub Intervention vs. control on the quality of SDM. Aim 2. Compare the effect of the Hypospadias Hub Decision Support Intervention vs. control on decisional conflict, decision-relevant knowledge, and decisional regret. Aim 3. Assess barriers and …
A Randomized Clinical Trial Evaluating Combination Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of Proliferative Diabetic Retinopathy
A
Amir Hajrasouliha
D
Denis Jusufbegovic, MD
This study will evaluate the safety and efficacy of two treatment strategies for PDR: faricimab plus PRP and Vitrectomy with endolaser with the goal to determine whether either approach decreases visit and treatment burden along with decreasing complications compared with the other treatment method while maintaining good visual acuity. The …
A Global Phase 3 Open-Label Extension Study to Assess the Long-Term Safety, Tolerability, and Efficacy of Intravenous AOC 1001 for the Treatment of Myotonic Dystrophy Type 1
A
Adam Comer
To evaluate the long-term safety and tolerability of AOC 1001 in DM1 patients.THIS STUDY IS ENROLLING BY INVITATION ONLY - The study will invite participants with DM1 who completed a prior study with AOC 1001 to participate.
Testing the Addition of the Anti-Cancer Drug Venetoclax And/Or the Anti-Cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed Kmt2A-Rearranged or Kmt2A-Non-Rearranged Leukemia
A
Amanda J. Saraf, DO
This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL) with a KMT2A gene rearrangement (KMT2A-rearranged [R]) or without a KMT2A gene rearrangement (KMT2A-germline [G]). Venetoclax is in a class of medications called B-cell lymphoma-2 (Bcl-2) …
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