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Found 697 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study of Investigational Medication for Teens with Belly Pain and Bathroom Trouble

E
Erik David Andrewski
12 years - 17 years
All genders
Interventional
This study investigates the effects of an investigational medication for treating Irritable Bowel Syndrome with Constipation (IBS-C) in teenagers. IBS-C is a condition where the belly hurts and there is trouble going to the bathroom. This study is for children aged 12 to less than 18 years old.During the study, …
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Study on Regional Radiotherapy in Low Risk Node Positive Breast Cancer

Y
Yunjie Lin, MD
R
Richard Zellars, MD
40 years - 100 years
Female
This study investigates the effects of receiving regional radiotherapy compared to no regional radiotherapy in patients with low risk node positive breast cancer. Breast cancer is a disease where cells in the breast grow uncontrollably. This study includes two study arms. In one arm, participants who had breast conserving surgery …
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Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT

K
Karl Shively
L
Luke A. Lopas, MD
18 years - 64 years
All genders
Phase 3
Interventional
The proposed study is a multi-center, prospective randomized controlled trial comparingurrent standard of care treatment to the SEXTANT treatment protocol in patients with Typeures of the tibia and IIIB fractures of the ankle and hindfoot.
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A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

S
Sandeep Batra, MD
21 years or below
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acuteyeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop …
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Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

J
James Chmiel
1 year - 11 years
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability andy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembraneductance regulator (CFTR) gene.
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Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

L
Leslie Hulvershorn, MD, MSc
10 years - 17 years
All genders
Phase 3
Interventional
This study investigates the safety and tolerability of an investigational medication in young people with schizophrenia or bipolar disorder. Schizophrenia is a mental disorder that affects how a person thinks, feels, and behaves. Bipolar disorder is a condition that causes extreme mood swings, including emotional highs (mania or hypomania) and …
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A Multicenter, Open-Label, Extension Clinical trial to evaluate Safety and Efficacy of Saroglitazar Magnesium in Participants with Primary Biliary Cholangitis (PBC)

R
Raj Vuppalanchi, MD
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This clinical trial (a medical research study) is an open-label extension of a previous research study, SARO.21.001, which evaluates the efficacy (improvement in liver enzymes and lipid profiles) and safety (side effects) of Saroglitazar Magnesium in participants with a medical condition known as Primary …
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A Prospective, Single-Arm Multi-Center Study of the HARMONIC 700, 5 mm Diameter Shears with Advanced Hemostasis in Pediatric Surgical Procedures (General) and Adult Surgical Procedures (General, Gynecological, Urological, and Thoracic)

T
Troy Markel, MD
110 years or below
All genders
Interventional
What is the purpose of this study?The main purpose of this study is to demonstrate acceptable performance and assess safety of the HARMONIC 700 Shears device in a post-market setting when used per the instructions for use in pediatric and adult surgical procedures.THIS STUDY IS ENROLLING BY INVITATION ONLY - …
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A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
What is the purpose of this study?This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily. Translational Objectives: 1. To preliminarily assess IHC hormone receptor expression and correlation …
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MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

N
Noel Dasgupta
18 years - 100 years
All genders
Phase 3
Interventional
What is the purpose of this study?To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM. 
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