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Found 685 results for in-health

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study (STOP360AG)

C
Cynthia Brown, MD
6 years or above
All genders
Phase 4
Interventional
The purpose of this study is to look at pulmonary exacerbations in people with cysticbrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms inwith CF that needs medical intervention. Both …

A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Determine the Safety and Efficacy of Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

D
Damien G. Patel, MD
40 years - 100 years
All genders
Phase 2
Interventional
What is the goal of this study?Ifetroban prevents and treats lung fibrosis due to multiple causes (bleomycin, genetic, radiation). The purpose of this study is to determine the safety and efficacy of oral ifetroban compared to placebo in subjects with IPF. THIS STUDY IS ENROLLING BY INVITATION ONLY  

A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
What is the purpose of this study?This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily. Translational Objectives: 1. To preliminarily assess IHC hormone receptor expression and correlation …

Evaluating Disparities in Precision Oncology: An Observational Trial in the context of a Real-World Academic Practice Model (EDPO)

B
Bryan Schneider, MD
18 years or above
All genders
Observational
What is the purpose of this study?This is a non-randomized observational trial designed to collect detailed clinical, social determinant, and genomic data from patients enrolled in molecular oncology tumor boards across four comprehensive cancer centers.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not …

A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared with Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function

W
Wayne Gray
18 years - 100 years
All genders
Phase 3
Interventional
The purpose of this study is to investigate the effect of balcinrenone/dapagliflozin compared with dapagliflozin, on the risk of CV death, HF event with and without hospitalization, in patients with chronic HF, impaired kidney function, and who have had a recent HF event.THIS STUDY IS ENROLLING BY INVITATION ONLY

Letermovir Prophylaxis for Cytomegalovirus in Pediatric Hematopoietic Cell Transplantation

A
April Rahrig, MD
2 years - 18 years
All genders
Phase 3
This phase III trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children and adolescents after stem cell transplant. The treatments used to prepare for HCT reduce the body's natural infection-fighting ability and increase the likelihood of an infection with a virus called …

A Phase 3, Prospective, Open-label, Uncontrolled, Multicenter Study onEfficacy and Safety of Prophylaxis with rVWF in Children Diagnosed With Severe von Willebrand disease

K
Kerry Hege, MD
17 years or below
All genders
Phase 3
Interventional
What is the purpose of this study?The main aim of the study is to evaluate the effectiveness of prophylaxis with recombinant von Willebrand factor (rVWF) in children. This study will enroll those participants who have been previously treated with VWF product or with a plasma-derived VWF (pdVWF) product.  

Workforce and System Change to Treat Adolescent Opioid Use Disorder within Integrated Pediatric Primary Care

L
Leslie Hulvershorn, MD, MSc
12 years - 100 years
All genders
Interventional
What is the purpose of this study?This project seeks to address the increasing risk of overdose death, substance use disorder (SUD), and opioid use disorder (OUD) in adolescents. The investigators believe that pediatric primary care providers (PCP) could play an important role in helping youth with SUD because most adolescents …

A phase 1, open-label, single arm study to evaluate pharmacokinetics, safety, and tolerability of Saroglitazar Magnesium dosed on alternate days in subjects having moderate hepatic impairment with cirrhosis due to cholestatic liver disease

R
Raj Vuppalanchi, MD
18 years - 80 years
All genders
Phase 1
Interventional
To evaluate PK after Saroglitazar Magnesium 1 mg dose on alternate days in subjects with moderate hepatic impairment with cirrhosis due to CLD based on Child-Pugh-Turcotte (CPT) score.To assess safety and tolerability of Sa-roglitazar Magnesium 1 mg dose on alter-nate days in subjects with moderate hepatic impairment with cirrhosis due …

Geometric Engineering of Liver Organoid Culture in Pediatric Liver Diseases

C
Chao Jarasvaraparn
17 years or below
All genders
Observational
What is the purpose of this study?Chronic liver disease (CLD) in children can be caused by a variety of conditions and have serious consequences if left untreated. Liver organoids are defined as 3D structure derived from human liver tissue and is a promising new approach to treating liver disease in …
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