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Found 702 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study of Investigational Medication for Teens with Belly Pain and Bathroom Trouble

E
Erik David Andrewski
12 years - 17 years
All genders
Interventional
This study investigates the effects of an investigational medication for treating Irritable Bowel Syndrome with Constipation (IBS-C) in teenagers. IBS-C is a condition where the belly hurts and there is trouble going to the bathroom. This study is for children aged 12 to less than 18 years old.During the study, …
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PREVENTion of Clot in Orthopaedic Trauma (PREVENT CLOT): A Randomized Pragmatic Trial Comparing the Complications and Safety of Blood Clot Prevention Medicines Used in Orthopaedic Trauma Patients

R
Roman Natoli, MD
100 years or below
All genders
The purpose of this research study is to help determine the best treatment for preventing blood clots that are formed following trauma that could potentially lead to death. At the moment researchers do not know if using medications called low molecular weight heparin or aspirin is better in preventing life …
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study (STOP360AG)

C
Cynthia Brown, MD
6 years or above
All genders
Phase 4
Interventional
The purpose of this study is to look at pulmonary exacerbations in people with cysticbrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms inwith CF that needs medical intervention. Both …
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Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

L
Leslie Hulvershorn, MD, MSc
10 years - 17 years
All genders
Phase 3
Interventional
This study investigates the safety and tolerability of an investigational medication in young people with schizophrenia or bipolar disorder. Schizophrenia is a mental disorder that affects how a person thinks, feels, and behaves. Bipolar disorder is a condition that causes extreme mood swings, including emotional highs (mania or hypomania) and …
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A Multicenter, Open-Label, Extension Clinical trial to evaluate Safety and Efficacy of Saroglitazar Magnesium in Participants with Primary Biliary Cholangitis (PBC)

R
Raj Vuppalanchi, MD
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This clinical trial (a medical research study) is an open-label extension of a previous research study, SARO.21.001, which evaluates the efficacy (improvement in liver enzymes and lipid profiles) and safety (side effects) of Saroglitazar Magnesium in participants with a medical condition known as Primary …
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A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
What is the purpose of this study?This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily. Translational Objectives: 1. To preliminarily assess IHC hormone receptor expression and correlation …
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Impact of Intravitreal Pegcetacoplan Treatment on Systemic Complement Levels in Age Related Macular Degeneration: A pilot study

A
Amir Hajrasouliha
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This study aims to understand how a new eye treatment, Pegcetacoplan, affects levels of certain proteins in the blood (complement proteins) that are linked to age-related macular degeneration and to measure the progression rate of the disease based on OCT landmarks using standard pretrained …
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A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in Patients With Postural Orthostatic Tachycardia Syndrome

A
Alex Barboi
18 years - 55 years
All genders
Phase 2
Interventional
What is the purpose of this study?This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS.The aim of the study is to see how safe, tolerable, and effective the study drug is.The study is looking at several other research questions, …
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Study of Investigational Medication in Individuals with Liver Disease

R
Raj Vuppalanchi, MD
18 years - 80 years
All genders
Phase 1
Interventional
This study investigates the effects of an investigational medication on people with moderate liver problems and cirrhosis caused by a liver condition called cholestatic liver disease. The purpose is to understand how the body processes the medication and how safe it is for these individuals. Cirrhosis is a condition where …
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Geometric Engineering of Liver Organoid Culture in Pediatric Liver Diseases

C
Chao Jarasvaraparn
17 years or below
All genders
Observational
What is the purpose of this study?Chronic liver disease (CLD) in children can be caused by a variety of conditions and have serious consequences if left untreated. Liver organoids are defined as 3D structure derived from human liver tissue and is a promising new approach to treating liver disease in …
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