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Found 703 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study of Investigational Treatment for Slow-Growing Brain Tumors in Children and Young Adults

S
Sandeep Batra, MD
2 years - 21 years
All genders
Phase 3
Interventional
This study investigates treatment options for children and young adults with low-grade glioma (LGG), a type of brain tumor. The purpose of this study is to compare the effects of an investigational medication with standard chemotherapy treatments, carboplatin and vincristine, in patients who do not have a specific genetic mutation …
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Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

J
Jodi Skiles
All genders
Observational
The primary purpose of the Research Sample Repository is to make blood samples available forh studies related to histocompatibility and hematopoietic cell transplantation (HCT)her cellular therapy. Representatives of participating centers and investigators or research groups may requesth samples contained in the Research Sample Repository for the purpose ofducting research including: …
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A phase 1b/2, multicenter, adaptive, double-blind, randomized, placebo-controlled study to assess the safety, tolerability, immunogenicity, and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in adults with Down syndrome (ABATE)

J
Jill Fostad
35 years - 50 years
All genders
Phase 1/2
Interventional
What is this study about?The purpose of this study is to assess the safety, tolerability, immunogenicity and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndrome.This phase 1b/2 study will be in 2 parts. Study Part 1 will involve subjects with prodromal …
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A Phase 1 Trial of Targeted Immunotherapy with Daratumumab Following Myeloablative Total Body Irradiation (TBI)-Based Conditioning and Allogeneic Hematopoietic Cell Transplantation in Children, Adolescents and Young Adults with High-Risk T-Cell Acute Lymphoblastic Leukemia and Lymphoma

J
Jodi Skiles
1 years - 39 years
All genders
Phase 1
What is the purpose of this study?A Phase I trial to determine the safety of targeted immunotherapy with daratumumab (DARA) IV after total body irradiation (TBI)-based myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for children, adolescents, and young adults (CAYA) with high risk T-cell acute lymphoblastic leukemia (T-ALL) or …
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Investigating Immune Responses in Children After Liver Transplant

A
Abby Russi
19 years or below
All genders
Observational
This study investigates the immune responses in children who have had a liver transplant. The purpose is to understand how the body's immune system acts before and during a problem called acute cellular rejection, which can happen after a transplant. Acute cellular rejection is when the body's immune system attacks …
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Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis: A Database Repository

M
Mohammad Al-Haddad, MD
18 years or above
All genders
What is the purpose of this study?The purpose of having a database is to collect data related to endoscopic procedures performed by Indiana University physicians specifically for the treatment of gastroparesis. This data will be used for research purposes only to determine the clinical impact of endoscopic treatments on gastroparesis. …
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Oral manifestations of the severity of COVID-19

M
Mythily Srinivasan
18 years - 100 years
All genders
This study is being conducted to help determine whether specific proteins and other markers in saliva can predict development of taste changes, gum health and diabetes in previously coronavirus-2 infected patients with persistent symptoms or long COVID-19. 
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Stigma in Lung Cancer and Tobacco-Related Cancers

B
Bharathi Muthusamy
18 years - 100 years
All genders
This study investigates the stigma experienced by patients with lung cancer and other tobacco-related cancers, such as pancreatic adenocarcinoma, renal cell carcinoma, and urothelial carcinoma. A stigma is a mark of disgrace associated with a particular condition. The purpose of this study is to understand how stigma affects patients with …
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Investigating the Effectiveness of Investigational Medicine in Metastatic or Recurrent Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 3
This study investigates the effectiveness and safety of an investigational medication compared to the investigator's choice of monotherapy treatment in patients with head and neck squamous cell carcinoma (HNSCC) that is incurable, metastatic, or recurrent. HNSCC is a type of cancer that occurs in the squamous cells lining the head …
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A Phase III Trial of One vs. Two Years of Maintenance Olaparib, with or without Bevacizumab, in Patients with BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy

J
Jessica Parker Metter
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme …
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