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Found 723 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Non-randomized Open-label Multi-center Phase I/II Study of Phosphatidylinositol-3-kinase (PI3K) Inhibitor Copanlisib in Pediatric Patients With Relapsed/Refractory Solid Tumors or Lymphoma

J
James Croop, MD, PhD
1 years - 21 years
All genders
This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with solid solid tumors or lymphoma that are recurrent or refractory to standard therapy.
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A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

N
Noel Dasgupta
18 years or above
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the safety and tolerability of extended dosing withwith hereditary transthyretin-mediated amyloid polyneuropathy (hATTR-PN).
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Research Study on the Safety and Effects of an Investigational Medication with Radiation in Children with High Grade Glioma

B
Brian Weiss
12 months - 22 years
All genders
Phase 1
This study investigates the safety and effects of an investigational medication when combined with radiation therapy in children with high grade glioma. High grade glioma is a type of cancer that occurs in the brain. The investigational medication works by blocking signals that make cancer cells grow, which may help …
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Studying Special Bandages for Hard-to-Heal Wounds

M
Mithun Sinha
18 years - 100 years
All genders
Interventional
This study investigates the effects of using a tri-layer amnion graft or a single-layer amnion graft for patients with hard-to-heal diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs). These ulcers are wounds that are difficult to heal and may require special treatments. The study compares these treatments to a …
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Investigating Pacing Methods for Heart Failure Treatment

T
Tony Navarrete
18 years - 100 years
All genders
Interventional
This study investigates two pacing methods for treating heart failure in patients with a specific heart condition. Heart failure is when the heart can't pump blood as well as it should. The study is comparing two types of cardiac-resynchronization therapy (CRT): biventricular pacing and pacing at the His or left …
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Investigation of Treatment Combinations for Advanced Non-Small Cell Lung Cancer

R
Rohan Maniar
18 years - 100 years
All genders
Phase 2/3
This study investigates the effects of adding an investigational medication, cemiplimab, to the usual treatment of docetaxel and ramucirumab for patients with stage IV or recurrent non-small cell lung cancer. This type of lung cancer is advanced and may have returned after previous treatment. Cemiplimab is a monoclonal antibody that …
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Phase II Randomized Double-Blind Study of mFOLFIRINOX plus Ramucirumab versus mFOLFIRINOX plus placebo in Advanced Pancreatic Cancer Patients HCRN GI14-198

18 years - 100 years
All genders
The purpose of this study is to find out what effects, good and/or bad, there are to adding the drug ramucirumab (RAM) to the usual chemotherapy regimen.
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Alnylam ALN-APP-001: Phase I, placebo-controlled trial of ALN-APP in participants with Early-Onset Alzheimer’s disease

J
Jared Brosch, MD
18 years - 100 years
All genders
Phase 1
Interventional
Who is Eligible Ages 18+ Must have had symptoms of Alzheimer’s disease prior to age 65 Diagnosis of Alzheimer’s disease Must be able to complete MRI Must be able to tolerate lumbar puncture No history of seizures, stroke or cancer in the last 5 years What is Involved In-person visits …
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Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV

N
Naga Chalasani, MD
18 years - 80 years
All genders
Observational
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions associated withumulation that ranges from benign, non-progressive liver fat accumulation to severever injury, cirrhosis, and liver failure. NAFLD is the most common liver disease in USdults and the second leading cause for liver transplantation in the US. The natural …
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A Non-interventional, Prospective, Multi-country Study Collecting Real-world Data on the Characteristics, Treatment Patterns, and Outcomes of Patients With Transthyretin (ATTR) Amyloidosis

N
Noel Dasgupta
18 years or above
All genders
Observational
What is the purpose of this study?MaesTTRo is an international, longitudinal, non-interventional study of adult patients with transthyretin (ATTR) amyloidosis. The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and …
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