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Found 165 Neoplasm trials

A listing of Neoplasm medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Comparative Effectiveness of Interventions to Improve Screening Among Rural Women

V
Victoria Champion
50 years - 74 years
Female
The purpose of this study is to compare the effectiveness of a tailored interactive DVD (TIDVD) vs telephone patient navigation (PN) + tailored interactive DVD (TIDVD) vs Usual Care in increasing screening rates for Breast Cancer (BC), Cervical Cancer (CC), and colorectal cancer (CRC) among women 50 -74 years living …
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Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Brain Metastases from Small Cell Lung Cancer.

K
Kevin Shiue
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. …
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Investigating the Safety and Effects of an Investigational Antibody-Drug Conjugate in Solid Tumors

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 1
This study investigates the safety and effects of an investigational antibody-drug conjugate in patients with advanced or metastatic solid tumors. The purpose is to understand how the investigational medication works in the body and its impact on tumors. Advanced or metastatic solid tumors are cancers that have spread beyond their …
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Investigation of Combination Therapy for Advanced Biliary Tract Cancer

A
Anita Turk, MD
18 years - 100 years
All genders
Phase 2
This study investigates the effects of combining investigational medications with standard chemotherapy for advanced biliary tract cancer. Biliary tract cancer is a type of cancer that affects the bile ducts, which are tubes that carry bile from the liver to the gallbladder and small intestine. The purpose of this study …
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A Phase I Study of Intra-Tumoral Injections of Ex Vivo Expanded Natural Killer Cells in Children and Young Adults With Recurrent or Progressive Supratentorial Malignant Brain Tumors

S
Scott Coven
1 years - 38 years
All genders
Phase 1
What is this study about?This phase I trial tests the safety, side effects, and best dose of ex vivo expanded natural killer cells in treating patients with cancerous (malignant) tumors affecting the upper part of the brain (supratentorial) that have come back (recurrent) or that are growing, spreading, or getting …
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A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1/2
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
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A Protocol for Children and Young Adults Diagnosed with a Central Nervous System (CNS) Tumor to Assess Cognitive, Quality of Life (QOL), and Comprehensive Effects of Therapies

S
Scott Coven
39 years or below
All genders
What is the purpose of this study?To longitudinally assess cognitive outcomes using an a neurocognitive screening battery in children and young adults diagnosed with a CNS tumor. To longitudinally assess the impact of specific therapies on the QOL in children and young adults diagnosed with a CNS tumor.To longitudinally assess …
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Investigating Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult (AYA) Childhood Cancer Survivors

S
Sandeep Batra, MD
15 years - 20 years
All genders
This study investigates a home-based physical activity program designed for Hispanic or Latino/Latina adolescent and young adult (AYA) childhood cancer survivors. After cancer treatment, some AYA survivors may experience long-term effects like weight gain, tiredness, and reduced fitness. Hispanic or Latino/Latina survivors might face a higher risk of these effects. …
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Research Study on Investigational Medication for HER2 Expressing Tumors

J
Jonathan L. Berkowitz, MD, PhD
18 years - 120 years
All genders
Phase 2
Interventional
This study investigates an investigational medication for treating certain tumors that express a protein called HER2. HER2 is a protein that can affect the growth of some cancer cells. The study includes different types of cancers such as bladder, biliary tract, cervical, endometrial, ovarian, pancreatic, and some rare tumors.Participants will …
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Study on Medication for Appetite Loss in Cancer

S
Susan Ballinger
18 years - 100 years
All genders
Phase 3
This study investigates the effects of an investigational medication on appetite loss in patients with advanced cancer. Advanced cancer means the cancer has spread to other parts of the body. The purpose of this study is to compare the investigational medication with another usual medication to see which one is …
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