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Found 161 Neoplasm trials

A listing of Neoplasm medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A PHASE III TRIAL OF THE IMPACT OF SENTINEL LYMPH NODE MAPPING ON PATIENT REPORTED LOWER EXTREMITY LIMB DYSFUNCTION IN ENDOMETRIAL CANCER

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 3
This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial cancer. Standard lymph node dissection removes lymph nodes around the uterus during a hysterectomy …
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Phase 1 Imaging Study of 68Ga-R10602 in Hormone Receptor-Positive Breast Cancer

K
Kathy Miller, MD
18 years - 100 years
All genders
Phase 1
What is the purpose of this study?This trial studies how well 68-Ga RM2 works with PET/MRI in imaging patients with estrogen receptor-positive breast cancer. 68-Ga-RM2 is an agent used in diagnostic imaging.Primary: To describe the safety of 68Ga-R10602.Secondary - To describe the biodistribution of 68Ga-R10602 in Study Participants with hormone …
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Investigation of Treatment Combinations for Advanced Non-Small Cell Lung Cancer

R
Rohan Maniar
18 years - 100 years
All genders
Phase 2/3
This study investigates the effects of adding an investigational medication, cemiplimab, to the usual treatment of docetaxel and ramucirumab for patients with stage IV or recurrent non-small cell lung cancer. This type of lung cancer is advanced and may have returned after previous treatment. Cemiplimab is a monoclonal antibody that …
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Immunotherapy After Surgery for Early-Stage Non-Small Cell Lung Cancer

R
Rohan Maniar
18 years - 100 years
All genders
This study investigates the use of an investigational medication in treating people with early-stage non-small cell lung cancer (NSCLC) after surgery. NSCLC is a type of lung cancer that occurs when cells in the lung grow uncontrollably. The purpose of this study is to see if the investigational medication can …
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Neoadjuvant pembrolizumab in patients with muscle-invasive bladder cancer with selective bladder sparing

J
Jennifer King
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?Subjects with cT2-T3N0M0 urothelial cancer of the bladder will be enrolled. After completingwo cycles of pembrolizumab, subjects will undergo a restaging MRI of the abdomen and pelvis with a standard acquisition protocol (as outlined in the protocol) as well as CT chest. A CThe …
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National Liver Cancer Screening Trial (TRACER)

N
Naga Chalasani, MD
18 years - 85 years
All genders
What is this study about?The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using …
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Investigating Chemoradiation (Combination of Chemotherapy and Radiation Therapy) for Early Stage Vulvar Cancer

S
Sharon E. Robertson
18 years - 100 years
Female
Phase 2
This study investigates the safety of using chemoradiation instead of surgery for early stage vulvar cancer. Vulvar cancer is a type of cancer that affects the external female genitalia. In some cases, cancer spreads to nearby lymph nodes. This study looks at patients with a macrometastasis, which means the cancer …
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Investigating the Effectiveness of Investigational Medicine in Metastatic or Recurrent Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 3
This study investigates the effectiveness and safety of an investigational medication compared to the investigator's choice of monotherapy treatment in patients with head and neck squamous cell carcinoma (HNSCC) that is incurable, metastatic, or recurrent. HNSCC is a type of cancer that occurs in the squamous cells lining the head …
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Cardiovascular Health Study in Testicular Cancer Survivors

N
Nabil Adra, MD
18 years - 100 years
Male
The purpose of this study is to investigate the long-term effects of chemotherapy and bone marrow transplant on the heart health of testicular cancer survivors. Testicular cancer often affects young adult males, and the treatment can include chemotherapy with platinum-based drugs. This study looks at changes in cholesterol, hormones, and …
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Study on the Use of Investigational Medication with Targeted Therapy for Cancer that has Spread from the Pancreas

A
Anita Turk, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates the use of an investigational medication along with a targeted therapy called olaparib for patients with metastatic pancreatic cancer. Metastatic pancreatic cancer is when the cancer has spread from the pancreas to other parts of the body. The study focuses on patients with specific genetic mutations called …
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