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Found 165 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)

T
Tarah Ballinger, MD
18-60 years
Female
Phase 3
What is this study about?This study will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and …
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Detection of late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin chemotherapy and bone marrow transplant

S
Suparna C. Clasen, MD, MSCE
18-100 years
Male
Why is this study being done?Testicular cancer (TC) is diagnosed in young adult males between ages 18-39 and TC treatment involves the use of platinum therapy (CBCT) which can have long-term cardiovascular effects. We are looking at cholesterol and hormone changes, as well as blood vessel changes for coronary artery …
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Using a Novel Lay Patient Navigation Model to Improve Cascade Testing Rates for Hereditary Cancer Syndromes in Black Patients and Their Family Members

N
Nawal Kassem
18-100 years
All genders
What is the purpose of this study?The purpose of this study is to improve genetic testing rates in families of Black patients who are found to have a hereditary cancer syndrome.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are …
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A COG Soft Tissue Sarcoma Biology and Banking Protocol

S
Sandeep Batra, MD
50-100 years
All genders
The purpose of this study is to better diagnose certain types of cancer.
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Biomarkers of endothelial dysfunction in pediatric patients receiving high intensity chemotherapy/irradiation

J
Jodi Skiles
18 years and younger
All genders
The purpose of this study is to collect blood specimens and data from patients undergoing stem cell transplant.
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A first-in-human, Phase I Study to Evaluate the Safety of TTX-080, an HLA-G Antagonist, in Subjects with Advanced Solid Tumors

G
Greg Durm, MD
18-100 years
All genders
Phase 1
To assess the safety and tolerability of TTX-080
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Phase II Trial of Panitumumab Nivolumab and Ipilimumab for KRAS/NRAS/BRAF Wild-type MSS Refractory Metastatic Colorectal Adenocarcinoma

P
Patrick Loehrer, MD
18-100 years
All genders
The purpose of this research study is to learn more about the safety and anti-cancer activity of a 3-drug combination therapy involving antibodies nivolumab, ipilimumab and panitumumab.
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Long-Term Adverse Health Outcomes in Survivors of Germ Cell Tumors Treated with High Dose Chemotherapy

M
Mohammad Abu Zaid, MD
18-65 years
Male
Observational
The purpose of this study is to compare men who were treated for testicular cancer and received high dose cisplatin-based chemotherapy and peripheral blood stem cell transplant to those who received conventional doses of cisplatin-based chemotherapy for treatment of the same disease and men who have never been diagnosed with …
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A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

N
Nabil Adra, MD
All genders
Phase 2
Interventional
The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib forwith incurable, refractory germ cell tumors. Patients will be treated until evidencedisease progression, non-compliance with study protocol, unacceptable major toxicity, atubject's own request for withdrawal, or if the study closes for any reason.
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Pilot ex-vivo investigation of an experimental beta probe for assessment and guidance of prostate cancer resection

C
Clinton Bahler, MD
18-100 years
All genders
68Ga-PSMA is a radiopharmaceutical used with PET imaging for the detection of prostate cancer under a compassionate IND in patients who have presented with biochemical failure. In this study, the use of 68Ga-PSMA-11 will be extended to newly diagnosed patients with high risk prostate cancer. Patients enrolled to this study …
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