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Found 118 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Master Screening and Reassessment Protocol (MSRP) for TierAdvancement in the NCI myeloMATCH Clinical Trials

R
Rita Assi
18 years - 100 years
All genders
What is the purpose of this study?This MyeloMATCH Master Screening and Reassessment Protocol (MSRP) evaluates the use of a screening tool and specific laboratory tests to help improve participants' ability to register to clinical trials throughout the course of their myeloid cancer (acute myeloid leukemia or myelodysplastic syndrome) treatment. This …
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Investigational Study of Maintenance Therapy in Ovarian Cancer with HER2 Protein

J
Jessica Parker
18 years - 100 years
Female
Phase 3
This study investigates the effectiveness of an investigational medication in combination with another medication compared to the other medication alone as a first-line maintenance therapy for patients with HER2-expressing ovarian cancer. HER2 is a protein that can affect the growth of some cancer cells. This study focuses on advanced high-grade …
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Investigating the Safety of an Investigational Treatment for a Type of Cancer Affecting White Blood Cells

H
Huda Salman
18 years - 100 years
All genders
Phase 1
This study investigates the safety of an investigational treatment using special immune cells called CAR-T cells for people with certain B cell cancers. B cell malignancies are cancers that affect a type of white blood cell. The study includes participants whose cancer has returned or not responded to previous treatments. …
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Investigating Safety and Effectiveness of an Investigational Medication for Low-grade Upper Tract Urothelial Cancer

H
Hristos Kaimakliotis, MD
18 years - 100 years
All genders
Phase 1/2
This study investigates the safety and effectiveness of an investigational medication for adults with low-grade upper tract urothelial carcinoma (LG-UTUC). LG-UTUC is a type of cancer that occurs in the urinary system, specifically the upper part of the ureter and kidney. The study will involve a safety lead-in period for …
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Investigation of an Investigational Medication for Advanced Solid Tumors with FGFR3 Alterations

T
Tareq Salous
18 years - 100 years
All genders
Phase 1
This study investigates the safety, side effects, and effectiveness of an investigational medication in treating advanced solid tumors with FGFR3 alterations, including metastatic urothelial cancer. FGFR3 is a gene that, when altered, can contribute to the growth of cancer cells. The purpose of this study is to understand how the …
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Study on Effects of Investigational for Refractory Metastatic Colorectal Cancer in Minority Populations

A
Anita Turk, MD
18 years - 100 years
All genders
Phase 4
This study investigates the effects of an investigational medication on high blood pressure in patients with refractory metastatic colorectal cancer (mCRC) from minority groups, specifically Black/African American and Hispanic/Latino populations. High blood pressure, also known as hypertension, is when the force of blood against the artery walls is too high, …
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Investigating the Safety and Effects of an Investigational Antibody-Drug Conjugate in Solid Tumors

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 1
This study investigates the safety and effects of an investigational antibody-drug conjugate in patients with advanced or metastatic solid tumors. The purpose is to understand how the investigational medication works in the body and its impact on tumors. Advanced or metastatic solid tumors are cancers that have spread beyond their …
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PSMA-PET to Guide Prostatectomy: A Sub-study

C
Clinton Bahler, MD
18 years - 100 years
Male
What is the purpose of this study?This sub-study consists of a single treatment group of men that require a PET scan to guide their radical prostatectomy, every subject will receive an MRI and the PSMA (prostate specific membrane antigen) PET scan prior to their surgery to determine if the PSMA …
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Testing the Addition of Chemotherapy Drug, Cisplatin, to Usual Radiation Therapy for Patients with Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 2
Interventional
The purpose of this study is to compare two treatment approaches that are currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone. A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin.
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Study on Investigational Cord Blood Units

J
Jodi Skiles
100 years or below
All genders
This study investigates the safety of using investigational cord blood units (CBUs) for hematopoietic stem cell transplants in both children and adults. Hematopoietic stem cells are important for creating new blood cells. The study will carefully look at any problems that happen during or after the infusion of these CBUs.Participants …
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