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Found 121 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigating Treatments for Colorectal Cancer That Has Spread

A
Anita Turk, MD
18 years - 100 years
All genders
Phase 3
This study investigates treatments for metastatic colorectal cancer, which is a type of cancer that starts in the colon or rectum and spreads to other parts of the body. The purpose of this study is to compare two treatments: one using an investigational medication with a chemotherapy regimen called mFOLFOX6, …
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Study of Investigational Medication with Hormone Treatment for Advanced Breast Cancer

T
Tarah Ballinger, MD
18 years - 100 years
All genders
Phase 3
This study investigates an investigational medication combined with other treatments for adults with advanced breast cancer that is hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-). Participants must have a specific gene change called a PIK3CA mutation and their cancer must have spread to other parts of …
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Study on the Use of Investigational Medication with Targeted Therapy for Cancer that has Spread from the Pancreas

A
Anita Turk, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates the use of an investigational medication along with a targeted therapy called olaparib for patients with metastatic pancreatic cancer. Metastatic pancreatic cancer is when the cancer has spread from the pancreas to other parts of the body. The study focuses on patients with specific genetic mutations called …
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Prospective Validation of a Points Score System Predicting 30-day Survival

N
Naoyuki Saito, MD
18 years or above
All genders
Phase 2
Observational
What is the purpose of this study?This is a one-stage single-arm phase II clinical trial designed to prospectively test the survival prediction tool as developed by Lee et al on patients referred to radiation oncologyve treatments. Survival prediction score based on objective data includingboratory values, attendance to emergency room, and …
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Ovarian Tissue Cryopreservation for Fertility Preservation in Pre and Post-Pubertal Children, Adolescents and Adults Facing a Fertility Threatening Diagnosis or Treatment Regimen

A
Amanda J. Saraf, DO
17 years or below
Female
What is the purpose of this study?Define and follow-up with the patients that undergo OTC for fertility preservation.Optimize techniques and quality assurance measures for freezing and thawing of ovarian tissue or gametesEstablish techniques for in vitro follicle maturation (IFM) or in vitro maturation of cumulus oocyte complexesInvestigate factors affecting successful …
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A Randomized Phase II Study Comparing Cytarabine + Daunorubicin(7+3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin +Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome+ Venetoclax in Patients Aged 59 or Younger Who are Considered High-Risk(Adverse) Acute Myeloid Leukemia as Determined by MYELOMATCH; AMyeloMATCH Clinical Trial

R
Rita Assi
18 years - 59 years
All genders
Phase 2
What is the purpose of this study?This phase II MyeloMATCH treatment trial tests whether the standard approach of cytarabine and daunorubicin in comparison to the following experimental regimens works to shrink cancer in patients with high risk acute myeloid leukemia (AML): 1) daunorubicin and cytarabine liposome alone; 2) cytarabine and …
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Study on Autologous Stem Cell Transplant for Peripheral T-Cell Lymphoma in Remission

U
Utpal Dave, MD
18 years - 75 years
All genders
Phase 3
This study investigates the potential benefits of using high dose chemotherapy followed by a patient's own stem cells, known as an autologous stem cell transplant, in treating peripheral T-cell lymphoma. Peripheral T-cell lymphoma is a type of cancer that affects T-cells, which are part of the body's immune system. The …
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Investigating the Effect of Gemcitabine with BCG for Recurrent Bladder Cancer

H
Hristos Kaimakliotis, MD
18 years - 100 years
All genders
This study investigates the effect of adding gemcitabine to intravesical Bacillus Calmette Guerin (BCG) for patients with recurrent non-muscle invasive bladder cancer. Non-muscle invasive bladder cancer is a type of cancer that affects the bladder but does not invade the muscle layer. Gemcitabine is a chemotherapy drug that stops cancer …
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Study on Treatment After Initial Therapy for Residual Triple Negative Breast Cancer

B
Bryan Schneider, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates treatments for patients with residual triple negative breast cancer, a type of breast cancer that does not have estrogen, progesterone, or HER2 receptors. The study uses circulating tumor DNA (ctDNA) to assign participants to different treatment arms based on their genomic markers. Participants with ctDNA positivity and …
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Study on Monitoring Symptoms During Cancer Treatment Using Surveys

J
Jordan Holmes
18 years - 100 years
All genders
This study investigates how completing surveys about symptoms and quality of life during radiation treatment affects symptom management. The focus is on patients who speak English or Spanish and are undergoing treatment for certain cancers, like endometrial, cervical, or prostate cancer. The goal is to see if real-time feedback can …
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