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Found 165 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

A
Anita Turk, MD
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). BRCA1 and BRCA2 are …
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Neoadjuvant pembrolizumab in patients with muscle-invasive bladder cancer with selective bladder sparing

J
Jennifer King
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?Subjects with cT2-T3N0M0 urothelial cancer of the bladder will be enrolled. After completingwo cycles of pembrolizumab, subjects will undergo a restaging MRI of the abdomen and pelvis with a standard acquisition protocol (as outlined in the protocol) as well as CT chest. A CThe …
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Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual Triple Negative Breast Cancer (PERSEVERE)

B
Bryan Schneider, MD
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?This is a 3-arm study stratified by plasma ctDNA. Patients with residual TNBC disease afterve therapy will be assigned to 1 of 3 Arms based on plasma ctDNA positivity and genomic marker(s).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, …
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PSMA-PET to Guide Prostatectomy

C
Clinton Bahler, MD
40-80 years
Male
Phase 2/3
Interventional
What is the purpose of this study?This study will randomize subjects to either standard of care MRI prior to radical prostatectomy or standard of care MRI and the PSMA (prostate specific membrane antigen) PET scan prior to radical prostatectomy to see if this scan will be helpful in detecting prostate …
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Dose Escalation Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab (Pembro) in Patients With Selected Advanced or Metastatic Solid Tumors

M
Mateusz Opyrchal, MD, PhD
18-100 years
All genders
Phase 1
Interventional
What is the purpose of this study?This is a first-in-human, Phase I, open-label, multicenter study designed to evaluate they, tolerability and preliminary efficacy of WTX-124, a conditionally-activated IL-2drug, when administered as monotherapy and in combination with pembrolizumab, for thewith advanced solid tumors. THIS STUDY IS ENROLLING BY INVITATION ONLY - …
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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

S
Sandeep Batra, MD
1-21 years
All genders
Phase 3
Interventional
What is the purpose of this study?Rhabdomyosarcoma is a type of cancer that occurs in the soft tissues in the body. This phaseutcomes in patients with very low risk rhabdomyosarcoma (VLR-RMS) while decreasing the burden of therapy using treatment with 24 weeks of vincristined dactinomycin (VA) and examines the use …
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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

S
Sandeep Batra, MD
1-50 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effect of open thoracic surgery (thoracotomy) tohoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgeryype of surgery done through a single larger incision (like …
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Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

N
Nabil Adra, MD
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?This is an open label randomized phase II trial of maintenance oral etoposide vs. observationwith relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood(PBSCT).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened …
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Exercise in Metastatic Breast Cancer: EMBody

T
Tarah Ballinger, MD
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?The purpose of this study is to study exercise in a novel population with indolent MBC (nogression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensitybic and resistance training exercise for …
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Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer (STAR)

S
Sharon E. Robertson
18 years and older
Female
Phase 2
Interventional
What is the purpose of this study?The purpose of this research study is to test the safety of Niraparib and dostarlimab as abination treatment and see what effects (good and bad) this combination treatment has onwith recurrent or progressive cervix cancer.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with …
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