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Found 146 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Phase II Trial of Panitumumab Nivolumab and Ipilimumab for KRAS/NRAS/BRAF Wild-type MSS Refractory Metastatic Colorectal Adenocarcinoma

P
Patrick Loehrer, MD
18-100 years
All genders
The purpose of this research study is to learn more about the safety and anti-cancer activity of a 3-drug combination therapy involving antibodies nivolumab, ipilimumab and panitumumab.
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Long-Term Adverse Health Outcomes in Survivors of Germ Cell Tumors Treated with High Dose Chemotherapy

M
Mohammad Abu Zaid, MD
18-65 years
Male
Observational
The purpose of this study is to compare men who were treated for testicular cancer and received high dose cisplatin-based chemotherapy and peripheral blood stem cell transplant to those who received conventional doses of cisplatin-based chemotherapy for treatment of the same disease and men who have never been diagnosed with …
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A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

N
Nabil Adra, MD
All genders
Phase 2
Interventional
The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib forwith incurable, refractory germ cell tumors. Patients will be treated until evidencedisease progression, non-compliance with study protocol, unacceptable major toxicity, atubject's own request for withdrawal, or if the study closes for any reason.
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Exercise in Metastatic Breast Cancer: EMBody

T
Tarah Ballinger, MD
18 years and older
All genders
Phase 2
Interventional
The purpose of this study is to study exercise in a novel population with indolent MBC (nogression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensitybic and resistance training exercise for 16 weeks in this population will …
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Pilot ex-vivo investigation of an experimental beta probe for assessment and guidance of prostate cancer resection

C
Clinton Bahler, MD
18-100 years
All genders
68Ga-PSMA is a radiopharmaceutical used with PET imaging for the detection of prostate cancer under a compassionate IND in patients who have presented with biochemical failure. In this study, the use of 68Ga-PSMA-11 will be extended to newly diagnosed patients with high risk prostate cancer. Patients enrolled to this study …
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A Phase 2 Study of the MEK Inhibitor Trametinib in Children With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

S
Sandeep Batra, MD
21 years and younger
All genders
This phase II trial studies how well trametinib works in treating patients with juvenile myelomonocytic leukemia that has come back or does not respond to treatment.
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Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

S
Steven Westphal, MD
45-74 years
Female
This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer.
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A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors

G
Greg Durm, MD
18-100 years
All genders
Phase 1/2
To determine the recommended Phase 2 dose (RP2D) of LY3537982 monotherapy in patients with KRAS G12C-mutant advanced solid tumors
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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer (PALAVY)

K
Kathy Miller, MD
18 years and older
All genders
Phase 2
Interventional
This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who areund to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgeryd standard adjuvant therapy.
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Key Adverse Events Following Childhood Cancer

S
Sandeep Batra, MD
21 years and younger
All genders
The goal of this study is to identify subjects who are more likely to develop a late-occurring complication(s) after undergoing treatment for childhood cancer.
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