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Found 151 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Using Circulating Tumor DNA to Personalize Duration of Consolidation Durvalumab

N
Nasser Hanna, MD
18 - 100
All genders
Phase 2
Interventional
What is the purpose of this study?This research aims to incorporate ctDNA analysis into clinical practice to individualize therapy in patients with stage III NSCLC by moving to a treatment-by-marker based approach (as opposed to treatment based on clinical or radiographic evidence of disease).THIS STUDY IS ENROLLING BY INVITATION ONLY …
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GammaTile and Stupp in Newly Diagnosed GBM (GESTALT)

M
Mitesh Shah, MD
18 - 100
All genders
Phase 4
Interventional
What is the purpose of this study?This study seeks to explore if GT, given its unique radiobiological and physical characteristics, may permit safe dose escalation and intensification and thereby provide a benefit to newly diagnosed GBM patients in terms of OS and LC when incorporated into the framework of the …
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A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer (CAPTAIN)

S
Shadia Jalal, MD
40 - 80
Male
Interventional
What is the purpose of this study? The purpose of this research study is to: Test whether the TULSA Study Procedure preserves or improves your quality of life (urinary, bowel and sexual functions) at 12 months post-study treatment compared to standard of care (radical prostatectomy). Test how many subjects who …
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Phase II Trial of Carboplatin +/- Tocilizumab for Metastatic Triple Negative and ER-low Breast Cancers

K
Kathy Miller, MD
18 or above
All genders
Phase 2
Interventional
What is the purpose of this study?This is a randomized Phase II study of carboplatin monotherapy vs. carboplatin combined with tocilizumab in in Black and non-Black patients with metastatic triple negative or ER low breast cancer. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients …
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Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

L
Lisa Landrum, MD, PhD, MS
18 or above
Female
Phase 2/3
Interventional
What is the purpose of this study?This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin HylectaTM) or pertuzumab, trastuzumab and hyaluronidase-zzxf (PhesgoTM) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma. Trastuzumab and pertuzumab are monoclonal …
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Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA)

L
Lisa Landrum, MD, PhD, MS
18 or above
All genders
Phase 3
Interventional
What is the purpose of this study?GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression.THIS STUDY IS ENROLLING BY INVITATION …
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Abatacept in Immune Checkpoint Inhibitor Myocarditis (ATRIUM)

S
Suparna C. Clasen, MD, MSCE
18 or above
All genders
Phase 3
Interventional
What is the purpose of this study?The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first …
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Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer (DeLLphi-304)

G
Greg Durm, MD
18 or above
All genders
Phase 3
Interventional
What is the purpose of this study?The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for …
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A Study of DSP107 Alone and in Combination With Atezolizumab for Patients With Advanced Solid Tumors

R
Rohan Maniar
18 or above
All genders
Phase 1/2
Interventional
What is the purpose of this study?Part 1: A first-in-human, open-label, Phase I dose escalation study of DSP107 monotherapy and combination therapy with atezolizumab in patients with advanced solid tumors. Part 2: Preliminary efficacy assessment of DSP107 in combination with atezolizumab in second or third line treatment of non small …
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ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

S
Suparna C. Clasen, MD, MSCE
40 or above
Male
Interventional
What is the purpose of this study?This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently taking androgen deprivation therapy (ADT) . THIS STUDY IS ENROLLING BY INVITATION ONLY - …
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