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Found 149 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer (CAPTAIN)

S
Shadia Jalal, MD
40 years - 80 years
Male
Interventional
What is the purpose of this study? The purpose of this research study is to: Test whether the TULSA Study Procedure preserves or improves your quality of life (urinary, bowel and sexual functions) at 12 months post-study treatment compared to standard of care (radical prostatectomy). Test how many subjects who …
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Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

L
Lisa Landrum, MD, PhD, MS
18 years or above
Female
Phase 2/3
Interventional
What is the purpose of this study?This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin HylectaTM) or pertuzumab, trastuzumab and hyaluronidase-zzxf (PhesgoTM) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma. Trastuzumab and pertuzumab are monoclonal …
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Abatacept in Immune Checkpoint Inhibitor Myocarditis (ATRIUM)

S
Suparna C. Clasen, MD, MSCE
18 years or above
All genders
Phase 3
Interventional
What is the purpose of this study?The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first …
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Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer (DeLLphi-304)

G
Greg Durm, MD
18 years or above
All genders
Phase 3
Interventional
What is the purpose of this study?The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for …
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A Study of DSP107 Alone and in Combination With Atezolizumab for Patients With Advanced Solid Tumors

R
Rohan Maniar
18 years or above
All genders
Phase 1/2
Interventional
What is the purpose of this study?Part 1: A first-in-human, open-label, Phase I dose escalation study of DSP107 monotherapy and combination therapy with atezolizumab in patients with advanced solid tumors. Part 2: Preliminary efficacy assessment of DSP107 in combination with atezolizumab in second or third line treatment of non small …
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ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

S
Suparna C. Clasen, MD, MSCE
40 years or above
Male
Interventional
What is the purpose of this study?This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently taking androgen deprivation therapy (ADT) . THIS STUDY IS ENROLLING BY INVITATION ONLY - …
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Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

V
Varun Mittal
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?This is a research study being done to see if adding a drug called epcoritamab to “salvage chemotherapy” GDP (gemcitabine + cisplatin, with dexamethasone) will better treat cancer than using chemotherapy alone.  THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology …
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A Phase 1/2 Multi-Center Trial of Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

A
April Rahrig, MD
3 years - 39 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?The purpose of this study is to determine the recommended phase 2 dose of the drug Vorinostat in children, adolescents and young adults following allogeneic blood or marrow transplant (BMT) and determine whether the addition of Vorinostat to the standard graft versus host disease …
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Phase 3 Study of Nemvaleukin Alfa in Combination With Pembrolizumab in Patients With Platinum-Resistant Epithelial Ovarian Cancer (ARTISTRY-7)

L
Lisa Landrum, MD, PhD, MS
18 years or above
Female
Phase 3
Interventional
What is the purpose of this study?This is a Phase 3, multicenter, open-label, randomized study of nemvaleukin in combination with pembrolizumab versus protocol-specific Investigator's choice chemotherapy in patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, …
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A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With The Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

B
Bryan Schneider, MD
18 years - 100 years
All genders
Phase 3
Interventional
What is the purpose of this study?This Phase III, randomized, open-label, multicenter study will evaluate the efficacy andy of giredestrant plus everolimus compared with the physician's choice of endocrineherapy plus everolimus in participants with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer …
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