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Found 146 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

DORA Trial: Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

N
Nabil Adra, MD
18-100 years
Male
Phase 3
What is the purpose of this study?The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetaxel alone. Earlier studies helped show that the combination is safe, but the combination has not been proven to work better …
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Randomized Phase II/III Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients With Unresectable Stage III or Stage IV Melanoma

T
Theodore Logan, MD
18-100 years
All genders
Phase 1/2
What is the purpose of this study?This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have …
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Development of a Genetic Algorithm to Predict Anthracycline-Induced Cardiomyopathy in Adult Patients

T
Todd Skaar
18-100 years
All genders
What is the purpose of this study?The purpose of this prospective study is to assess the accuracy of four previously-studied genetic variations to predict the development of cardiomyopathy (i.e., a disease of the heart muscle that reduces the ability of your heart to pump blood to your body) in adult …
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Sentinel lymph node biopsy for cutaneous squamous cell carcinoma of the head and neck

J
Jessica Yesensky, MD
18-100 years
All genders
What is the purpose of this study?The purpose of this study is to research if a type of biopsy known as sentinel lymph node biopsy (SLNB) can help in determining the rate of tumor deposits that are hard to detect and identify in node-negative cutaneous squamous cell carcinoma of the …
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Evaluation of the Hereditary Component of Localized Prostate Cancer

C
Courtney Schroeder
18-100 years
Male
Observational
What is the purpose of this study?Our goals of the study include (1) Evaluating whether we can identify “at-risk” patients with localized prostate cancer who have positive germline mutations not previously known, (2) Identifying which, if any, specific pre-identified “at-risk” population groups are individually at an increased risk of carrying …
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Evaluating a 3D Printed Oral Stent Device with Suction for Oral Cancer RT

M
Mark Langer, MD
18-100 years
All genders
What is the purpose of this study?A foam bite is the standard device used to hold the tongue in place during radiation treatment of cancers of the tongue. There is no device currently available to fix the tongue in place and remove oral secretions (i.e. saliva) through suction tubing attached …
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IU Pancreatic Lesion Tissue/Fluid Bank

C
C. Max Schmidt, MD, PhD
12-100 years
All genders
What is the purpose of this study?The purpose of the study is to prospectively collect tissue/fluid specimens from patients with pancreatic lesions for the purpose of developing novel disease biomarkers which may provide improved diagnosis, prognosis, and treatment of patients with these lesions. All specimens with the exception of blood and …
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Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder (ADAPT)

N
Nabil Adra, MD
18-100 years
All genders
Phase 1/2
What is the purpose of this study?The main purpose of this phase 1 trial is to show that durvalumab is safe when given alone, in combination with BCG treatments, and in combination with radiation therapy. The overall goal of this trial is to see if the risk of your cancer …
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TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer

R
Richard Zellars, MD
40-100 years
Female
What is the purpose of this study?The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not …
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A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently With Radiotherapy Versus Radiotherapy Alone for Inflammatory Breast Cancer

R
Richard Zellars, MD
18-100 years
All genders
Phase 2
What is the purpose of this study?This phase II trial studies how well radiation therapy with or without olaparib works in treating patients with inflammatory breast cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Olaparib may stop the growth of tumor cells by blocking …
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