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Found 151 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Pilot Study of a Rapid Triadic Communication Intention Elicitation Intervention (PRECursOr) to Improve Supportive Oncology Care Delivery for Patients with Advanced, Incurable Cancer and their Caregivers

K
Kristin Levoy
18 - 100
Female
What is this study about?The purpose of this study is to help test an idea designed to foster more supportive talk between providers (doctors or nurse practitioners), patients, and caregivers during an outpatient oncology appointment. A caregiver is the person the patient identifies is primarily involved in their healthcare. This …
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A phase 1A dose escalation study of LP-184 in patients with advanced or metastatic solid tumors

M
Misty D. Shields, MD, PhD
18 - 100
All genders
Phase 1/2
What is the purpose of this study? Primary Objective :-To evaluate the safety, tolerability, MTD and theRP2D of LP-184 in patients with advanced solid tumors who have relapsed from or are refractory to standard therapy or for whom no standard therapy is availableSecondary Objective:-To characterize the PK of LP-184 and its …
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A Phase II trial Evaluating Safety and Efficacy of Epcoritamab with Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

V
Varun Mittal
18 - 100
All genders
Phase 2
What is the purpose of this study?Estimate complete remission (CR) rate per the Lugano classification with a combination of epcoritamab and GDP in subjects with relapsed large cell lymphoma.Estimate overall response rate (ORR) per the Lugano classification with a combination of epcoritamab and GDP in subjects with relapsed large cell …
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Development of a Genetic Algorithm to Predict Anthracycline-Induced Cardiomyopathy in Adult Patients

T
Todd Skaar
18 - 100
All genders
What is the purpose of this study?The purpose of this prospective study is to assess the accuracy of four previously-studied genetic variations to predict the development of cardiomyopathy (i.e., a disease of the heart muscle that reduces the ability of your heart to pump blood to your body) in adult …
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SHORTER ANTHRACYCLINE-FREE CHEMO IMMUNOTHERAPY ADAPTED TOPATHOLOGICAL RESPONSE IN EARLY TRIPLE NEGATIVE BREAST CANCER (SCARLET), ARANDOMIZED PHASE III STUDY

K
Kathy Miller, MD
16 - 100
All genders
Phase 3
What is this study about?This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill …
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A Phase III Randomized Trial For Newly Diagnosed Multiple Myeloma (NDMM) Patients Considered Frail Or In A Subset of “Intermediate Fit” Comparing Upfront Three-Drug Induction Regimens Followed by Double- or Single-Agent Maintenance.

A
Attaya Suvannasankha, MD
18 - 100
All genders
Phase 3
What is this study about?This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment …
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Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study

S
Shadia Jalal, MD
18 - 100
All genders
Phase 3
What is this study about?This trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Ramucirumab is a monoclonal antibody that …
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Real-Time Monitoring of Patient Centered Outcomes in English And Non-English-Speaking Patients Undergoing Radiation Treatment and its Impact on Overcoming Language Barriers

J
Jordan Holmes
18 - 100
All genders
What is the purpose of this study?The purpose of this study is to evaluate if asking patients to complete surveys about their symptoms and quality of life during radiation treatment in real time improves management of symptoms and side effects commonly experienced during radiation treatment. THIS STUDY IS ENROLLING BY …
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Evaluating Different Methods of Circulating Tumor DNA Quantification in Oncology Patients

T
Tim Lautenschlaeger, MD
18 - 100
Accepts healthy volunteer
All genders
What is the purpose of this study?This study aims to invent a test that can see tiny pieces from people with cancer (specifically DNA from a person’s cancer) in blood and urine better than tests that can currently be done. In the future, this test can possibly be used to …
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National Liver Cancer Screening Trial (TRACER)

N
Naga Chalasani, MD
18 - 85
All genders
What is this study about?The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using …
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