Found 98 results for will-simon
A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Forager-2: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Vepugratinib Combined with Enfortumab Vedotin and Pembrolizumab in Adults with Untreated Locally Advanced or Metastatic Urothelial Carcinoma with an Fgfr3 Genetic Alteration.
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Tareq Salous
This phase II clinical trial tests how well pembrolizumab plus enfortumab vedotin prior to and after radical nephroureterectomy works in treating patients with high-risk upper tract urothelial cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability …
A Randomized, Active-Controlled, Double-Blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with Folfox Versus Bevacizumab in Combination with Folfox for the First-Line Treatment of Metastatic Colorectal Cancer
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Anita Turk, MD
Primary ObjectiveTo compare the progression-free survival (PFS) as assessed by blinded Independent. Radiological Review Committee (IRRC) based on Response Evaluation Criteria in. Solid Tumors (RECIST) v1.1, of ivonescimab in combination with modified 5-FU, oxaliplatin, and leucovorin (mFOLFOX6) to bevacizumab in combination with mFOLFOX6.Secondary ObjectivesTo compare the overall survival (OS) of …
Docetaxel Addition In Metastatic Castrate-Sensitive Prostate Cancer (Aspire)
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Nabil Adra, MD
This phase III trial compares the effect of adding docetaxel to hormonal therapy and apalutamide versus hormonal therapy and apalutamide alone in treating patients with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Docetaxel is in a class of …
A Randomized, Open-Label Study Evaluating The Efficacy And Safety Of Cemacabtagene Ansegedleucel In Participants With Minimal Residual Disease After Response To First Line Therapy For Large B-Cell Lymphoma (Alpha3)
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Varun Mittal
This is a randomized, open-label study in adult patients who have completed standard first line therapy for large B-cell lymphoma (LBCL) and achieved a complete response or partial response suitable for observation, but who have minimal residual disease (MRD) as detected by the Foresight CLARITY™ Investigational Use Only (IUO) MRD …
Randomized, Open-Label Study of the Bria-Imt Regimen and Check Point Inhibitor Vs Physician S Choice in Advanced Metastatic Breast Cancer (Bria-Abc)
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Tarah Ballinger, MD
The purpose of this study is to evaluate the effect of the Bria-IMT regimen in combination with Check Point Inhibitor (CPI) on overall survival (OS) compared to treatment of physician’s choice (TPC) chemotherapy in patients with metastatic breast cancer with no approved alternative therapies available as per the Inclusion criter …
A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Subjects With Relapsed/Refractory Multiple Myeloma
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Attaya Suvannasankha, MD
The purpose of this Phase 2 study is to assess the antimyeloma activity and further characterize the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cemsidomide in combination with dexamethasone in subjects with relapsed/refractory multiple myeloma (r/r MM).Interested in participating? For more information about this research study or other cancer-related …
Engaging your Brain for Memory Function
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Simon Davis
Join Us and Take Part in Brain Activity Research at Indiana University!Your brain is always working—helping you think, remember, and make decisions. This study is looking at how different parts of the brain work together.We are also studying a safe, non-invasive method called TMS (transcranial magnetic stimulation) to see how …
A Phase Ii Single-Arm Pilot Study of Hydroxychloroquine for the Treatment of Aromatase Inhibitor-Associated Musculoskeletal Syndrome (Aimss)
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Tarah Ballinger, MD
The purpose of this study is to evaluate the effectiveness of hydroxychloroquine sulfate (a type of drug commonly used to treat joint pain caused by inflammation, swelling) in reducing joint pain associated with Aromatase Inhibitor Associated Musculoskeletal Syndrome (AIMSS) for patients with breast cancer.Interested in participating? For more information about …
Organoid Model Predictive of Response to Immunotherapies
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Mateusz Opyrchal, MD, PhD
What is the purpose of this study?The purpose of this study is to create models out of tissue samples and treat those models with the same immunotherapy treatment the patient will be receiving, in order to validatehis process and to predict responses to therapies and use it to choose the …
Bespoke Pan Cancer
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Hristos Kaimakliotis, MD
This is a prospective, multi-center, single arm study focused on data and sample collection from participants diagnosed with Stage I to IV cancers and for whom standard of care Natera MRDtesting has been ordered (for example, SignateraTM, SignateraTM Genome, or LatitudeTM). This study will utilize study sites located within the …
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