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Found 165 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study

S
Shadia Jalal, MD
18-100 years
All genders
Phase 3
What is this study about?This trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Ramucirumab is a monoclonal antibody that …
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Registering Genomics and Imaging of Tumors

J
Jason Parker
18-89 years
All genders
What is the purpose of this study?This research is being done to see if genetic mutations inside brain tumors can be identified using pictures from MRI or PET scanners, instead of using needles or surgery. To conduct the study, we need to take pictures of the locations of tumor samples …
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Real-Time Monitoring of Patient Centered Outcomes in English And Non-English-Speaking Patients Undergoing Radiation Treatment and its Impact on Overcoming Language Barriers

J
Jordan Holmes
18-100 years
All genders
What is the purpose of this study?The purpose of this study is to evaluate if asking patients to complete surveys about their symptoms and quality of life during radiation treatment in real time improves management of symptoms and side effects commonly experienced during radiation treatment. THIS STUDY IS ENROLLING BY …
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National Liver Cancer Screening Trial (TRACER)

N
Naga Chalasani, MD
18-85 years
All genders
What is this study about?The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using …
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A Phase I/II, First-in-Human (FIH), Open-Label, Multiple Centre Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of LM-24C5 in Patients with Advanced Solid Tumors

M
Mateusz Opyrchal, MD, PhD
18-100 years
All genders
Phase 1/2
What is the purpose of this study?To assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D)/optimal biologic dose (OBD) and/or Maximum Tolerated Dose (MTD) for LM-24C5 in subjects with advanced solid tumors.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not …
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Rapid Autopsy Protocol for Patients with Small Cell Lung Cancer

S
Shadia Jalal, MD
18-100 years
All genders
What is the purpose of this study?This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection. This proposal is a collaboration between scientists, lung cancer physicians, pathologists, …
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A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of KB707 in Subjects with Locally Advanced or Metastatic Solid Tumor Malignancies

M
Mateusz Opyrchal, MD, PhD
18-100 years
All genders
Phase 1
What is the study purpose?KB707-01 is a Phase 1, open-label, multicenter, dose escalation and expansion study to evaluate the safety and tolerability of KB707 in adults with locally advanced or metastatic solid tumors who have progressed on standard of care therapy, cannot tolerate standard of care therapy, refused standard of …
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Organoid Model Predictive of Response to Immunotherapies

M
Mateusz Opyrchal, MD, PhD
18 years and older
All genders
Observational
What is the purpose of this study?The purpose of this study is to create models out of tissue samples and treat those models with the same immunotherapy treatment the patient will be receiving, in order to validatehis process and to predict responses to therapies and use it to choose the …
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Testing Health-Related Interventions: Voices of Equity Needed to Overcome Weight-bias in Obesity-Cancer Care THRIVE NOW in Obesity-Cancer Care

M
Misty Hawkins
21-100 years
All genders
What is the purpose of this study?There are long-standing inequities in interventions for obesity among Black Breast Cancer Survivors (BCS).  While the American Cancer Society provides recommendations regarding weight management for successful cancer survivorship, the guidelines are not specific to women or Blacks.  This 3-phase pilot study will address these …
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A Phase 3, Multicenter, Open-label Study to Test the Diagnostic Performance of Copper Cu 64 PSMA I&T PET/CT in Staging of Men with Newly Diagnosed Unfavorable Intermediate-risk, High-risk or Very High-risk Prostate Cancer Electing to Undergo Radical Prostatectomy with Pelvic Lymph Node Dissection

M
Mark Tann, MD
18-100 years
Male
Phase 3
Why is this study being done?To determine the diagnostic performance of copper Cu 64 PSMA I&T PET/CT for the detection of presence or absence of pelvic lymph node metastasis in pre-prostatectomy patients with unfavorable intermediate-risk, high-risk or very high-risk PC. The sensitivity of copper Cu 64 PSMA I&T PET/CT to …
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