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Found 129 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Evaluation of a System Under Investigation Using Clinical Blood Samples

T
Thomas E. Davis
18 years - 100 years
All genders
The purpose of this study is to evaluate an investigational system using clinical blood samples. This study investigates its performance by comparing results from the investigational system to established methods. The study involves three arms: Method Comparison, Whole Blood Precision, and WBC Flagging. Method Comparison assesses how closely the investigational …
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Study on Investigational Medication for Preventing Pancreatic Fluid Leakage After Surgery

R
Ryan Ellis
18 years - 100 years
All genders
Phase 3
This study investigates the use of an investigational medication to prevent postoperative pancreatic fistula (POPF) in patients undergoing distal pancreatectomy. POPF is a complication that can occur after surgery on the pancreas, where pancreatic fluid leaks from the surgical site. The study aims to compare the incidence of POPF in …
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Study of Imaging and Treatment Agents for Breast Cancer

K
Kathy Miller, MD
18 years - 100 years
All genders
Phase 1
This study investigates how safe and effective two investigational agents, an imaging agent and a therapeutic agent, are for patients with advanced breast cancer. The imaging agent, called 68Ga-R11228, is used to locate specific tumor cells in the body. The therapeutic agent, 177Lu-R11228, is used for treatment. Both agents are …
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ONCOLOGY CLINICIANS PERSPECTIVES ON TREATMENT DECISION-MAKING AND THE ACCEPTABILITY AND USABILITY OF THE INTERACTIVE WEB-ENABLED COMMUNICATION RESOURCES OF THE CLL/SLL CARE ROAD MAP

L
Larry Cripe, MD
18 years - 100 years
All genders
What is the purpose of this study?To characterize the way in which oncologists, oncology nurses, and oncology pharmacists evaluate the treatment options for patients with CLL/SLL and engage or support patients in shared decision-making.To test the acceptability and usability of the interactive web-enabled communication and decision-making resources of the CLL/SLL …
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Study Comparing Investigational Medication to Rituximab for Follicular Lymphoma

K
Khushali Jhaveri
18 years - 100 years
All genders
Phase 3
This study investigates the effectiveness of two treatments for people with a type of cancer called follicular lymphoma, which affects certain white blood cells. The purpose of this study is to compare an investigational medication with rituximab, which is a monoclonal antibody that attaches to a protein on cancer cells …
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Breast Cancer Treatment Monitoring Study

T
Tarah Ballinger, MD
18 years - 100 years
Female
This study investigates the use of the NearWave optical molecular monitoring system to track the progress of breast cancer treatment. The purpose is to see if this system can predict how well patients respond to chemotherapy before surgery. Breast cancer is a disease where cells in the breast grow uncontrollably. …
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A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1/2
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
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Evaluating Tolerability of Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT) with High Dose Rate Brachytherapy Boost for Unfavorable and Higher Risk Prostate Cancer

O
Omar Ishaq
18 years - 100 years
Male
What is the purpose of this study?The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods. Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of internal radiation where a cancer …
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Pursuing Exploration into the Supportive Care Needs and Intervention Preferences of Survivors of Testicular Cancer (PERSIST): A Mixed Methods Pilot Study

S
Shelley Johns
18 years or above
Male
What is the purpose of this study?In this 3-phase pilot, we will identify adverse health outcomes and unmet support needs of testicular cancer survivors (TCS) (Phase 1) and employ participatory co-design to adapt an existing acceptance and commitment therapy (ACT)-based intervention with a sample of up to 8 TCS (Phase …
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Study of Investigational Medication Administered During Breast-Conserving Surgery

C
Carla Fisher, MD
18 years - 100 years
All genders
Phase 1
This study investigates the safety and appropriate dosage of an investigational medication given to patients during breast-conserving surgery for breast cancer. Breast-conserving surgery involves removing the cancer while keeping as much normal breast as possible. The investigational medication is administered directly to the surgical site to assess its effects on …
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