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Found 113 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigating the Safety of an Investigational Treatment for a Type of Cancer Affecting White Blood Cells

H
Huda Salman
18 years - 100 years
All genders
Phase 1
This study investigates the safety of an investigational treatment using special immune cells called CAR-T cells for people with certain B cell cancers. B cell malignancies are cancers that affect a type of white blood cell. The study includes participants whose cancer has returned or not responded to previous treatments. …
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Study of Eye Health in Patients Using a Medication Being Studied for Cervical Cancer

S
Sharon E. Robertson
18 years - 100 years
Female
Phase 4
This study investigates the effects of an investigational medication on eye health in patients with recurrent or metastatic cervical cancer. Cervical cancer occurs when cells in the cervix grow uncontrollably. This study focuses on understanding any side effects related to the eyes that may arise from the treatment. A side …
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Molecular and Pathological Correlates of Treatment Outcome in Patients with Thymoma and Thymic Carcinoma

P
Patrick Loehrer, MD
1 years - 100 years
All genders
What is this study about?The major purpose of this research study is to obtain blood samples from child and adult patients diagnosed with thymoma and/or tissue samples from patients undergoing surgery for their thymoma.  We will use these specimens to test for certain characteristics that we think will be useful …
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Tissue Procurement Protocol for the Developmental Therapeutics Clinic National Cancer Institute (NCI)

A
Anna Maria Storniolo, MD
110 years or below
All genders
What is the purpose of this study?Adult patients (18 years of age and older) and pediatric patients (younger than 18 years of age) who are being evaluated for and/or treated for cancer at the NIH Clinical Center and at participating sites will be entered onto this tissue procurement protocol for …
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Testing the Addition of Chemotherapy Drug, Cisplatin, to Usual Radiation Therapy for Patients with Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 2
Interventional
The purpose of this study is to compare two treatment approaches that are currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone. A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin.
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Investigating the Effectiveness of Immunotherapy in Recurrent Endometrial Cancer

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
This study investigates the effectiveness of using a combination of investigational medications, nivolumab and ipilimumab, compared to nivolumab alone in treating patients with recurrent endometrial cancer. Endometrial cancer is a type of cancer that begins in the lining of the uterus. This study focuses on a specific type of endometrial …
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Investigating Chemoradiation (Combination of Chemotherapy and Radiation Therapy) for Early Stage Vulvar Cancer

S
Sharon E. Robertson
18 years - 100 years
Female
Phase 2
This study investigates the safety of using chemoradiation instead of surgery for early stage vulvar cancer. Vulvar cancer is a type of cancer that affects the external female genitalia. In some cases, cancer spreads to nearby lymph nodes. This study looks at patients with a macrometastasis, which means the cancer …
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A Randomized, Double-Blind, Placebo-Controlled Phase 3b Study to Evaluate the Short- and Long-Term Efficacy and Safety of Dual Targeted Therapy With Intravenous Vedolizumab and Oral Upadacitinib Compared With Intravenous Vedolizumab Monotherapy for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease

M
Monika Fischer, MD
18 years - 65 years
All genders
Phase 3
Interventional
What is the purpose of this study?The main aim of this study is to learn whether vedolizumab and upadacitinib given together (also called dual targeted therapy or DTT) reduces bowel inflammation and ulcers in the bowel compared to vedolizumab only (also called monotherapy) in adults with moderately or severely active …
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Study on Imaging Techniques for Prostate Cancer Surgery

C
Clinton Bahler, MD
18 years - 100 years
Male
This study investigates the use of a special scan called PSMA PET to guide surgery for prostate cancer. The purpose is to find out if the PSMA PET scan can better detect cancer near the edge of the prostate and help doctors plan the surgery. Prostate cancer is a disease …
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Study on Investigational Cord Blood Units

J
Jodi Skiles
100 years or below
All genders
This study investigates the safety of using investigational cord blood units (CBUs) for hematopoietic stem cell transplants in both children and adults. Hematopoietic stem cells are important for creating new blood cells. The study will carefully look at any problems that happen during or after the infusion of these CBUs.Participants …
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