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Found 122 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study Comparing Investigational Medication to Rituximab for Follicular Lymphoma

K
Khushali Jhaveri
18 years - 100 years
All genders
Phase 3
This study investigates the effectiveness of two treatments for people with a type of cancer called follicular lymphoma, which affects certain white blood cells. The purpose of this study is to compare an investigational medication with rituximab, which is a monoclonal antibody that attaches to a protein on cancer cells …
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Breast Cancer Treatment Monitoring Study

T
Tarah Ballinger, MD
18 years - 100 years
Female
This study investigates the use of the NearWave optical molecular monitoring system to track the progress of breast cancer treatment. The purpose is to see if this system can predict how well patients respond to chemotherapy before surgery. Breast cancer is a disease where cells in the breast grow uncontrollably. …
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A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1/2
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
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Evaluating Tolerability of Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT) with High Dose Rate Brachytherapy Boost for Unfavorable and Higher Risk Prostate Cancer

O
Omar Ishaq
18 years - 100 years
Male
What is the purpose of this study?The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods. Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of internal radiation where a cancer …
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Pursuing Exploration into the Supportive Care Needs and Intervention Preferences of Survivors of Testicular Cancer (PERSIST): A Mixed Methods Pilot Study

S
Shelley Johns
18 years or above
Male
What is the purpose of this study?In this 3-phase pilot, we will identify adverse health outcomes and unmet support needs of testicular cancer survivors (TCS) (Phase 1) and employ participatory co-design to adapt an existing acceptance and commitment therapy (ACT)-based intervention with a sample of up to 8 TCS (Phase …
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Investigational Treatment for Relapsed Metastatic Germ Cell Tumor

J
Jennifer King
18 years - 100 years
All genders
This study investigates the use of an investigational medication in combination with oral etoposide for patients with relapsed metastatic germ cell tumor (GCT). Germ cell tumors are a type of cancer that begins in the cells that give rise to sperm or eggs. This study is designed to find out …
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Research Study of an Investigational Device for Stress Urinary Incontinence After Prostate Surgery

M
Michael Koch, MD
45 years - 100 years
Male
This study investigates the use of an investigational device for men who have stress urinary incontinence after having their prostate removed because of cancer. Stress urinary incontinence happens when activities like coughing or lifting cause urine to leak. The purpose of this study is to see if the device is …
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Studying Low-Dose Aspirin's Effect on Inflammation in New Mothers

T
Tarah Ballinger, MD
18 years - 45 years
Female
Phase 2
This study investigates the effect of low-dose aspirin on inflammation markers in postpartum patients with benign breast disease. Postpartum refers to the period after childbirth. Chronic inflammation may increase the risk of developing breast cancer after having a baby. Low-dose aspirin is a type of medication that reduces inflammation and …
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Phase I trial of a chimeric (trastuzumab-like and pertuzumab-like) HER2 B cell peptide vaccine emulsified in ISA 720 adjuvant for locally advanced HER2 positive breast cancer

P
Pravin Kaumaya
18 years - 100 years
All genders
Phase 1
What is the purpose of this study?Primary Objectives1. To determine the safety and toxicity profile of a chimeric HER2 B-cell peptide vaccine in patients with high-risk HER2 positive breast cancer after completion of standard curative therapy and adjuvant HER2-directed antibody therapy2. To determine immune responses induced by a chimeric HER2 …
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Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy: A Prospective, Single-arm, Multi-center, Blinded-review, Phase 3 Diagnostic Performance Study

C
Clinton Bahler, MD
18 years - 100 years
Male
Phase 3
What is the purpose of this study?The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate …
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