A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Researchers as the Indiana University Simon Comprehensive Cancer Center are conducting a study to research the safety and effectiveness of increasing doses of CD4CAR T cell therapy for patients who have been diagnosed with, or are being treated for, relapsed or refractory (has not responded to treatment) CD4+ chronic myelomonocytic …
The purpose of this study is to evaluate an investigational system using clinical blood samples. This study investigates its performance by comparing results from the investigational system to established methods. The study involves three arms: Method Comparison, Whole Blood Precision, and WBC Flagging. Method Comparison assesses how closely the investigational …
This study investigates how safe and effective two investigational agents, an imaging agent and a therapeutic agent, are for patients with advanced breast cancer. The imaging agent, called 68Ga-R11228, is used to locate specific tumor cells in the body. The therapeutic agent, 177Lu-R11228, is used for treatment. Both agents are …
What is the purpose of this study?To characterize the way in which oncologists, oncology nurses, and oncology pharmacists evaluate the treatment options for patients with CLL/SLL and engage or support patients in shared decision-making.To test the acceptability and usability of the interactive web-enabled communication and decision-making resources of the CLL/SLL …
This study investigates the use of an investigational medication to prevent postoperative pancreatic fistula (POPF) in patients undergoing distal pancreatectomy. POPF is a complication that can occur after surgery on the pancreas, where pancreatic fluid leaks from the surgical site. The study aims to compare the incidence of POPF in …
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
What is the purpose of this study?The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods. Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of internal radiation where a cancer …
What is the purpose of this study?In this 3-phase pilot, we will identify adverse health outcomes and unmet support needs of testicular cancer survivors (TCS) (Phase 1) and employ participatory co-design to adapt an existing acceptance and commitment therapy (ACT)-based intervention with a sample of up to 8 TCS (Phase …
This study investigates the use of an investigational device for men who have stress urinary incontinence after having their prostate removed because of cancer. Stress urinary incontinence happens when activities like coughing or lifting cause urine to leak. The purpose of this study is to see if the device is …
This study investigates the safety and appropriate dosage of an investigational medication given to patients during breast-conserving surgery for breast cancer. Breast-conserving surgery involves removing the cancer while keeping as much normal breast as possible. The investigational medication is administered directly to the surgical site to assess its effects on …
