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Found 98 results for will-simon
A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Osteosarcoma Predisposition - Developing New Models to Study Pediatric Osteosarcoma Development
J
Jennifer Ivanovich
What is the purpose of this study?In partnership with Indiana Biosciences Research Institute, we will develop new models to study pediatric osteosarcoma. We will invite children with Li-Fraumeni syndrome, hereditary retinoblastoma syndrome, or Rothmund-Thompson syndrome to participate. These three syndromes are associated with an increased risk to develop osteosarcoma. THIS STUDY …
A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)
M
Mateusz Opyrchal, MD, PhD
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
Transperitoneal vs Extraperitoneal Retroperitoneal Lymph Node Dissection: A Prospective Randomized Controlled Trial
T
Timothy Masterson
We intend to compare an alternative way of performing cancer surgery for those who have testis cancer. This alternative technique is called extraperitoneal RPLND which has been published in retrospective studies. Its benefits, however, remain to be proved in a prospective study. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent …
Randomized prospective study comparing intrathecal morphine vs intravenous methadone for postoperative analgesia following retroperitoneal lymph node dissection (RPLND)
G
Gulraj Singh Chawla
At Indiana University Adult Academic Health Center (AAHC), both intrathecal morphine and intravenous methadone are the standard of care for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer, and both have had great success. In this study, we propose to compare their analgesic effectiveness at …
A Phase II trial Evaluating Safety and Efficacy of Epcoritamab with Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma
V
Varun Mittal
The goal of this study:Estimate complete remission (CR) rate per the Lugano classification with a combination of epcoritamab and GDP in subjects with relapsed large cell lymphoma.Estimate overall response rate (ORR) per the Lugano classification with a combination of epcoritamab and GDP in subjects with relapsed large cell lymphoma.Estimate duration …
Fear of Cancer Occurrence: Development and Initial Psychometric Testing of a Fear Measure for Breast Cancer Previvors
S
Shelley Johns
To develop a measure of cancer-related fear in previvors, women with an increased risk of developing breast cancer within their lifetime but have never had a cancer diagnosis. Two existing fear measures will be used to develop the initial fear of cancer occurrence (FOCO) measure, then two rounds of cognitive …
Expanded Access Program (EAP) for Ciltacabtagene Autoleucel (Cilta-Cel) Out-of-Specification (OOS) in Participants With Multiple Myeloma
R
Rafat Abonour, MD
What is the purpose of this study?The purpose of this expanded access program (EAP) is to provide ciltacabtagene autoleucel (cilta-cel) that does not meet the commercial release specifications of CARVYKTI and is notvailable via the local health care system in the country where the treatment is requested.THIS STUDY IS ENROLLING …
Pilot Study of a Rapid Triadic Communication Intention Elicitation Intervention (PRECursOr) to Improve Supportive Oncology Care Delivery for Patients with Advanced, Incurable Cancer and their Caregivers
K
Kristin Levoy
What is this study about?The purpose of this study is to help test an idea designed to foster more supportive talk between providers (doctors or nurse practitioners), patients, and caregivers during an outpatient oncology appointment. A caregiver is the person the patient identifies is primarily involved in their healthcare. This …
Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy: A Prospective, Single-arm, Multi-center, Blinded-review, Phase 3 Diagnostic Performance Study
C
Clinton Bahler, MD
What is the purpose of this study?The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate …
A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma
L
Lisa Landrum, MD, PhD, MS
What is the purpose of this study?This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily. Translational Objectives: 1. To preliminarily assess IHC hormone receptor expression and correlation …
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