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Found 118 will-simon trials
A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Development of a Genetic Algorithm to Predict Anthracycline-Induced Cardiomyopathy in Adult Patients
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Todd Skaar
What is the purpose of this study?The purpose of this prospective study is to assess the accuracy of four previously-studied genetic variations to predict the development of cardiomyopathy (i.e., a disease of the heart muscle that reduces the ability of your heart to pump blood to your body) in adult …
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Shadia Jalal, MD
The purpose of this study is to investigate a rapid autopsy program for patients with Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center. Small Cell Lung Cancer is a type of lung cancer characterized by fast-growing tumors. This study will involve collecting tumor tissue from …
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Greg Durm, MD
This study investigates the effectiveness and safety of an investigational medication compared to the investigator's choice of monotherapy treatment in patients with head and neck squamous cell carcinoma (HNSCC) that is incurable, metastatic, or recurrent. HNSCC is a type of cancer that occurs in the squamous cells lining the head …
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Michael W. Sim, MD
This study investigates a new approach for treating HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). The purpose of this study is to see if reducing the intensity of treatment, based on levels of ctHPVDNA (pieces of cancer DNA in blood samples), can be as effective as the standard treatment. OPSCC is …
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Jessica Parker Metter
What is the purpose of this study?This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme …
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Angela M. Richardson, MD, PhD
What is the purpose of this study?The purpose of this study is to look at the effect of oxygen on tumor tissue and cerebrospinal fluid(CSF). Tissue in your body is exposed to less oxygen than is in the air around you. Traditional studies use cells and tissue kept in room …
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Kathy Miller, MD
This study investigates the effects of different durations of HER2-targeted therapy in patients with early-stage HER2-positive breast cancer. HER2-positive breast cancer is a type of cancer where a protein called HER2 is found on the surface of the cancer cells. This protein can make cancer cells grow faster. The purpose …
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Rohan Maniar
This study investigates the use of an investigational medication in treating people with early-stage non-small cell lung cancer (NSCLC) after surgery. NSCLC is a type of lung cancer that occurs when cells in the lung grow uncontrollably. The purpose of this study is to see if the investigational medication can …
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Anita Turk, MD
This study investigates treatments for metastatic colorectal cancer, which is a type of cancer that starts in the colon or rectum and spreads to other parts of the body. The purpose of this study is to compare two treatments: one using an investigational medication with a chemotherapy regimen called mFOLFOX6, …
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Tarah Ballinger, MD
This study investigates an investigational medication combined with other treatments for adults with advanced breast cancer that is hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-). Participants must have a specific gene change called a PIK3CA mutation and their cancer must have spread to other parts of …
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