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Found 127 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Phase I trial of a chimeric (trastuzumab-like and pertuzumab-like) HER2 B cell peptide vaccine emulsified in ISA 720 adjuvant for locally advanced HER2 positive breast cancer

P
Pravin Kaumaya
18 years - 100 years
All genders
Phase 1
What is the purpose of this study?Primary Objectives1. To determine the safety and toxicity profile of a chimeric HER2 B-cell peptide vaccine in patients with high-risk HER2 positive breast cancer after completion of standard curative therapy and adjuvant HER2-directed antibody therapy2. To determine immune responses induced by a chimeric HER2 …
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Study on Decision-Making and Usability of Resources for Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL) Patients

L
Larry Cripe, MD
18 years - 100 years
All genders
This study investigates how patients with CLL/SLL make decisions about their treatment options. CLL stands for chronic lymphocytic leukemia, and SLL stands for small lymphocytic lymphoma, both of which are types of blood cancers. The study aims to understand patient perspectives on choosing between different treatments and to gather feedback …
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Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy: A Prospective, Single-arm, Multi-center, Blinded-review, Phase 3 Diagnostic Performance Study

C
Clinton Bahler, MD
18 years - 100 years
Male
Phase 3
What is the purpose of this study?The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate …
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A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
What is the purpose of this study?This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily. Translational Objectives: 1. To preliminarily assess IHC hormone receptor expression and correlation …
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A Phase 3, Randomized, Open-Label Study to Compare the Efficacy and Safety of Anitocabtagene Autoleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Multiple Myeloma

R
Rafat Abonour, MD
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory …
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Study of Investigational Medication vs Standard Treatments in Cancer That Has Spread

N
Nabil Adra, MD
18 years - 100 years
Male
Phase 3
This study investigates the treatment of metastatic castration-resistant prostate cancer (mCRPC), which is a type of cancer that continues to grow even when the amount of testosterone in the body is reduced to very low levels. The purpose of this study is to compare overall survival between participants receiving an …
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Routine Carbohydrate Loading in Patients Undergoing Complex Hepatobiliary Surgery

T
Tom Korte Maatman
18 years - 100 years
All genders
What is the purpose of this study?Test the effect of preoperative carbohydrate loading on hospital LOS after complex hepatopancreaticobiliary surgeries.Test the effect of preoperative carbohydrate loading on other post-operative complications including surgical site infections (SSI), readmissions, delayed gastric emptying (DGE), insulin resistance and deathTHIS STUDY IS ENROLLING BY INVITATION ONLY …
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Study of a Treatment Being Studied for Advanced Tumors and Lymphoma

R
Rohan Maniar
18 years - 100 years
All genders
Phase 1/2
This study investigates the use of an investigational medication in adults with advanced solid tumors or non-Hodgkin lymphoma (NHL). The purpose is to learn about the safety and effects of different doses and ways of giving the medication. Solid tumors are abnormal masses of tissue that can be cancerous, and …
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Study on Medication for Appetite Loss in Cancer

S
Susan Ballinger
18 years - 100 years
All genders
Phase 3
This study investigates the effects of an investigational medication on appetite loss in patients with advanced cancer. Advanced cancer means the cancer has spread to other parts of the body. The purpose of this study is to compare the investigational medication with another usual medication to see which one is …
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Detecting Prostate Cancer Return with Imaging

C
Clinton Bahler, MD
18 years - 100 years
Male
Phase 3
This study investigates how well a special scan can find prostate cancer that has come back after treatment. Prostate cancer is a disease where cells in the prostate grow out of control. The study uses a technique called PET/CT, which stands for Positron Emission Tomography and Computed Tomography. This scan …
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