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Found 129 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigation of an Investigational Medication for Advanced Solid Tumors with FGFR3 Alterations

T
Tareq Salous
18 years - 100 years
All genders
Phase 1
This study investigates the safety, side effects, and effectiveness of an investigational medication in treating advanced solid tumors with FGFR3 alterations, including metastatic urothelial cancer. FGFR3 is a gene that, when altered, can contribute to the growth of cancer cells. The purpose of this study is to understand how the …
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Phase II Randomized Double-Blind Study of mFOLFIRINOX plus Ramucirumab versus mFOLFIRINOX plus placebo in Advanced Pancreatic Cancer Patients HCRN GI14-198

18 years - 100 years
All genders
The purpose of this study is to find out what effects, good and/or bad, there are to adding the drug ramucirumab (RAM) to the usual chemotherapy regimen.
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Study on Effects of Investigational for Refractory Metastatic Colorectal Cancer in Minority Populations

A
Anita Turk, MD
18 years - 100 years
All genders
Phase 4
This study investigates the effects of an investigational medication on high blood pressure in patients with refractory metastatic colorectal cancer (mCRC) from minority groups, specifically Black/African American and Hispanic/Latino populations. High blood pressure, also known as hypertension, is when the force of blood against the artery walls is too high, …
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Investigating the Safety and Effects of an Investigational Antibody-Drug Conjugate in Solid Tumors

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 1
This study investigates the safety and effects of an investigational antibody-drug conjugate in patients with advanced or metastatic solid tumors. The purpose is to understand how the investigational medication works in the body and its impact on tumors. Advanced or metastatic solid tumors are cancers that have spread beyond their …
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PSMA-PET to Guide Prostatectomy: A Sub-study

C
Clinton Bahler, MD
18 years - 100 years
Male
What is the purpose of this study?This sub-study consists of a single treatment group of men that require a PET scan to guide their radical prostatectomy, every subject will receive an MRI and the PSMA (prostate specific membrane antigen) PET scan prior to their surgery to determine if the PSMA …
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Testing the Addition of Chemotherapy Drug, Cisplatin, to Usual Radiation Therapy for Patients with Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 2
Interventional
The purpose of this study is to compare two treatment approaches that are currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone. A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin.
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Study of Investigational Medication for Small-Cell Lung Cancer

M
Misty D. Shields, MD, PhD
18 years - 100 years
All genders
This study investigates the use of an investigational medication compared to durvalumab for people with limited-stage small-cell lung cancer (SCLC). Small-cell lung cancer is a type of cancer that starts in the lungs and is known for growing quickly. Participants in this study have already received chemotherapy and radiotherapy, which …
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Study on Investigational Cord Blood Units

J
Jodi Skiles
100 years or below
All genders
This study investigates the safety of using investigational cord blood units (CBUs) for hematopoietic stem cell transplants in both children and adults. Hematopoietic stem cells are important for creating new blood cells. The study will carefully look at any problems that happen during or after the infusion of these CBUs.Participants …
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Translational Breast Cancer Research Consortium Biospecimen & Outcomes Repository

K
Kathy Miller, MD
18 years - 100 years
Female
The purpose of this study is to develop a repository of clinical data and outcomes, with and without corresponding specimens from individuals who have participated in TBCRC studies.
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Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin

G
Greg Durm, MD
18 years - 100 years
All genders
The purpose of this study is to compare any good and bad effects of usual radiation plus the study treatment, MEDI4736 (durvalumab), to the usual therapy of radiation plus cetuximab in patients with head and neck cancer who cannot take the drug cisplatin.
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