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Found 702 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Research Study on Heart Failure and Kidney Function

W
Wayne Gray
18 years - 100 years
All genders
Phase 3
Interventional
This study investigates the effects of an investigational medication on heart failure and kidney function. Heart failure is a condition where the heart cannot pump blood as well as it should. This study compares the investigational medication to another treatment to see how they affect heart failure events and cardiovascular …
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Medicine to Prevent CMV Infection in Kids After Stem Cell Transplant

A
April Rahrig, MD
2 years - 18 years
All genders
Phase 3
This study investigates the use of an investigational medication to prevent cytomegalovirus (CMV) infection in children and adolescents who have undergone a stem cell transplant. Cytomegalovirus is a virus that can cause infections, especially in people with weakened immune systems. "Prophylaxis" means taking a drug to prevent a disease or …
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Study on Preventive Treatment with Investigational Medication for Severe von Willebrand Disease in Children

K
Kerry Hege, MD
17 years or below
All genders
Phase 3
Interventional
This study investigates the use of prophylaxis with an investigational medication in children diagnosed with severe von Willebrand disease. Von Willebrand disease is a bleeding disorder caused by low levels or dysfunction of von Willebrand factor, a protein that helps blood clot. This study aims to evaluate the effectiveness of …
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Impact of Intravitreal Pegcetacoplan Treatment on Systemic Complement Levels in Age Related Macular Degeneration: A pilot study

A
Amir Hajrasouliha
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This study aims to understand how a new eye treatment, Pegcetacoplan, affects levels of certain proteins in the blood (complement proteins) that are linked to age-related macular degeneration and to measure the progression rate of the disease based on OCT landmarks using standard pretrained …
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A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in Patients With Postural Orthostatic Tachycardia Syndrome

A
Alex Barboi
18 years - 55 years
All genders
Phase 2
Interventional
What is the purpose of this study?This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS.The aim of the study is to see how safe, tolerable, and effective the study drug is.The study is looking at several other research questions, …
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Workforce and System Change to Treat Adolescent Opioid Use Disorder within Integrated Pediatric Primary Care

L
Leslie Hulvershorn, MD, MSc
12 years - 100 years
All genders
Interventional
What is the purpose of this study?This project seeks to address the increasing risk of overdose death, substance use disorder (SUD), and opioid use disorder (OUD) in adolescents. The investigators believe that pediatric primary care providers (PCP) could play an important role in helping youth with SUD because most adolescents …
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Study of Investigational Medication in Individuals with Liver Disease

R
Raj Vuppalanchi, MD
18 years - 80 years
All genders
Phase 1
Interventional
This study investigates the effects of an investigational medication on people with moderate liver problems and cirrhosis caused by a liver condition called cholestatic liver disease. The purpose is to understand how the body processes the medication and how safe it is for these individuals. Cirrhosis is a condition where …
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Geometric Engineering of Liver Organoid Culture in Pediatric Liver Diseases

C
Chao Jarasvaraparn
17 years or below
All genders
Observational
What is the purpose of this study?Chronic liver disease (CLD) in children can be caused by a variety of conditions and have serious consequences if left untreated. Liver organoids are defined as 3D structure derived from human liver tissue and is a promising new approach to treating liver disease in …
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Investigational Medication for Protecting Egg-Producing Organs in Young Cancer Patients

T
Tarah Ballinger, MD
40 years or below
Female
Phase 3
This study investigates the effects of an investigational medication on protecting the ovaries in young females with cancer who are receiving chemotherapy. Chemotherapy, particularly with alkylating agents, can harm the ovaries, making it hard to get pregnant later. The investigational medication may help by slowing down the ovaries during chemotherapy, …
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A Historical Cohort, Multicenter Study to Characterize the Management, Clinical Course, and Outcomes of Pregnancies in Participants Who Have Experienced a Pregnancy With Severe HDFN

H
Hiba Mustafa, MD
18 years - 100 years
All genders
Observational
What is the purpose of this study?The purpose of this study is to better understand how pregnancies affected by severe Hemolytic Disease of the Fetus and Newborn (HDFN) are managed and what outcomes result from different treatment approaches. By analyzing past pregnancies from 2006 to 2023, this study aims to …
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