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Found 705 in-health trials

A listing of in-health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

DAY101 vs. Standard of Care Chemotherapy in Pediatric Patients With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

M
Michael Ferguson, MD
25 years or below
All genders
Phase 3
Interventional
What is the purpose of this study?This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in patients with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring front-line …
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A Multicenter Randomized Controlled Trial of Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia (The SURVENT Trial)

M
Mohammad Al-Haddad, MD
18 years or above
All genders
Interventional
What is the purpose of this study?The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. This is a multicenter study involving several academic, community and private hospitals around the United States. …
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Investigating the Effects of an Investigational Medication on Stress Responses After Motor Vehicle Collisions

P
Paul Musey, MD
18 years - 55 years
All genders
Interventional
This study investigates the effects of an investigational medication on reducing acute stress reactions and acute stress disorder following a motor vehicle collision. Acute stress reactions are immediate psychological responses to a traumatic event, which can develop into acute stress disorder if symptoms persist. The purpose of this study is …
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Research Study on Heart Failure and Kidney Function

W
Wayne Gray
18 years - 100 years
All genders
Phase 3
Interventional
This study investigates the effects of an investigational medication on heart failure and kidney function. Heart failure is a condition where the heart cannot pump blood as well as it should. This study compares the investigational medication to another treatment to see how they affect heart failure events and cardiovascular …
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Study on Investigational Medication for Early Alzheimer's Disease

J
Jared Brosch, MD
18 years - 85 years
All genders
Interventional
This study investigates the effects of an investigational medication on people with early Alzheimer's disease. Alzheimer's disease is a condition that affects memory and thinking skills. The purpose of this study is to learn more about the safety and effectiveness of the medication compared to a placebo, which is a …
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Study on Safety and Effects of Investigational Antibiotic in Infants

A
Anna Elizabeth Thomas
9 months or below
All genders
Phase 1/2
Interventional
This study investigates the safety and effects of an investigational medication for treating infections caused by gram-negative bacteria in newborns and infants. Gram-negative bacteria are a type of bacteria that can cause various infections and are known for their resistance to antibiotics. The investigational medication is a combination of two …
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Investigating the Safety and Effects of an Investigational Medication in Children with ANCA-associated Vasculitis

S
Stacey Tarvin, MD
6 years - 17 years
All genders
Phase 3
Interventional
This study investigates the safety and effects of an investigational medication combined with a regimen containing either rituximab or cyclophosphamide in children with ANCA-associated vasculitis (AAV). ANCA-associated vasculitis is a condition where the body's immune system mistakenly attacks blood vessels, causing inflammation. The study focuses on children aged 6 to …
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OnX Liver Assessment Solution Clinical Study

R
Raj Vuppalanchi, MD
22 years - 80 years
All genders
Interventional
What is the purpose of this study?This protocol’s primary aim is to assess the performance of the OnX exam on patients with suspected or confirmed liver disease with the goal of comparing the OnX output stiffness estimates to FibroScan® liver stiffness measurements. Our primary objectives are to assess whether the …
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Supplementation of Skeletal Survey with Whole Body MRI for Fracture Detection in Children with Suspected Physical Abuse

C
Christopher Newman
2 years or below
All genders
Interventional
What is the purpose of this study?Children with a skeletal survey for suspected physical abuse who are already receiving MR imaging for possible neurological injuries will be imaged with additional whole body MRI. They will also receive a clinical follow up skeletal survey, which will serve as the reference standard …
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Study on Preventive Treatment with Investigational Medication for Severe von Willebrand Disease in Children

K
Kerry Hege, MD
17 years or below
All genders
Phase 3
Interventional
This study investigates the use of prophylaxis with an investigational medication in children diagnosed with severe von Willebrand disease. Von Willebrand disease is a bleeding disorder caused by low levels or dysfunction of von Willebrand factor, a protein that helps blood clot. This study aims to evaluate the effectiveness of …
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